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Receive this page by email each issue: [Sign up for eTOCs] Other Issues: February 15 2008; 111 (4)   [Index by Author]  [Cover Caption]  [Complete Inside Blood PDF]         INSIDE BLOOD        ASH 50TH ANNIVERSARY REVIEW        PERSPECTIVE        REVIEW ARTICLES        CHEMOKINES, CYTOKINES, AND INTERLEUKINS        CLINICAL TRIALS AND OBSERVATIONS        GENE THERAPY        HEMATOPOIESIS        HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY        IMMUNOBIOLOGY        NEOPLASIA        PHAGOCYTES        RED CELLS        STEM CELLS IN HEMATOLOGY        TRANSPLANTATION        CORRESPONDENCE        ERRATUM Find articles in this issue containing these words: [Search ALL Issues] Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) | Advertising (PDF) To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. INSIDE BLOOD: Scavenger receptors: targets for antiplatelet therapies? Meinrad Gawaz Blood 2008 111: 1749-1750. [Full Text] [PDF]   RAGs found "not guilty": cleared by DNA evidence Albert G. Tsai and Michael R. Lieber Blood 2008 111: 1750. [Full Text] [PDF]   Attack of the CD4 clones Ineke J. M. ten Berge and René A. W. van Lier Blood 2008 111: 1750-1751. [Full Text] [PDF]   Is tandem autotransplantation necessary in myeloma? Sundar Jagannath Blood 2008 111: 1751-1752. [Full Text] [PDF]   New role for AML1/ETO in leukemogenesis Martin Carroll Blood 2008 111: 1752. [Full Text] [PDF]   Hemophilia lives: the impact of prophylaxis Louis M. Aledort Blood 2008 111: 1752-1753. [Full Text] [PDF]   PACAP: a new player in thrombopoiesis Jorge Di Paola Blood 2008 111: 1753-1754. [Full Text] [PDF]   Intentionally integrating in oncogenes David W. Russell Blood 2008 111: 1754. [Full Text] [PDF]   Do short telomeres shorten CLL survival? Thomas S. Lin Blood 2008 111: 1755. [Full Text] [PDF]   New entry for angiostatic cancer treatment Arjan W. Griffioen Blood 2008 111: 1755-1756. [Full Text] [PDF]   Dissecting "stress" in Fanconi anemia Inderjeet Dokal Blood 2008 111: 1756-1757. [Full Text] [PDF]   DAT ± AHA = bad CLL Martin J. S. Dyer Blood 2008 111: 1757. [Full Text] [PDF]   ASH 50TH ANNIVERSARY REVIEW: Telomeres, stem cells, and hematology Peter M. Lansdorp Blood 2008 111: 1759-1766. [Abstract] [Full Text] [PDF]   PERSPECTIVE: Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges Paolo Anderlini and Richard E. Champlin Blood 2008 111: 1767-1772. Prepublished online December 5, 2007; DOI 10.1182/blood-2007-07-097543 [Abstract] [Full Text] [PDF]   REVIEW ARTICLES: Monitoring the response and course of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: practical advice on the use and interpretation of monitoring methods Hagop Kantarjian, Charles Schiffer, Dan Jones, and Jorge Cortes Blood 2008 111: 1774-1780. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-09-110189 [Full Text] [PDF]   CHEMOKINES, CYTOKINES, AND INTERLEUKINS: Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFB activity Christine D. Palmer, Brenda E. Mutch, Sarita Workman, John P. McDaid, Nicole J. Horwood, and Brian M. J. Foxwell Blood 2008 111: 1781-1788. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-07-102343 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)–induced priming and activation of human basophils Becky M. Vonakis, Donald W. MacGlashan, Jr, Natalia Vilariño, Jacqueline M. Langdon, Rebecca S. Scott, and Susan M. MacDonald Blood 2008 111: 1789-1796. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-07-104364 [Abstract] [Full Text] [PDF]   Epigenetic regulation of dendritic cell–derived interleukin-12 facilitates immunosuppression after a severe innate immune response Haitao Wen, Yali Dou, Cory M. Hogaboam, and Steven L. Kunkel Blood 2008 111: 1797-1804. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-08-106443 [Abstract] [Full Text] [PDF] [Supplemental Figure]   CLINICAL TRIALS AND OBSERVATIONS: Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial Abderrahman Abdelkefi, Saloua Ladeb, Lamia Torjman, Tarek Ben Othman, Amel Lakhal, Neila Ben Romdhane, Halima El Omri, Moez Elloumi, Hatem Belaaj, Ramzi Jeddi, Lamia Aissaouï, Habib Ksouri, Assia Ben Hassen, Fahmi Msadek, Ali Saad, Mohamed Hsaïri, Kamel Boukef, Ahlem Amouri, Hechmi Louzir, Koussay Dellagi, and Abdeladhim Ben Abdeladhim, on behalf of the Tunisian Multiple Myeloma Study Group Blood 2008 111: 1805-1810. Prepublished online September 17, 2007; DOI 10.1182/blood-2007-07-101212 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Social participation of patients with hemophilia in the Netherlands Iris Plug, Marjolein Peters, Eveline P. Mauser-Bunschoten, Arja de Goede-Bolder, Lily Heijnen, Cees Smit, José Willemse, Frits R. Rosendaal, and Johanna G. van der Bom Blood 2008 111: 1811-1815. Prepublished online November 6, 2007; DOI 10.1182/blood-2007-07-102202 [Abstract] [Full Text] [PDF]   Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy Susan O'Brien, Farhad Ravandi, Todd Riehl, William Wierda, Xuelin Huang, Jeffrey Tarrand, Brandi O'Neal, Hagop Kantarjian, and Michael Keating Blood 2008 111: 1816-1819. Prepublished online November 26, 2007; DOI 10.1182/blood-2007-03-080010 [Abstract] [Full Text] [PDF]   The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia Claire Dearden, Rachel Wade, Monica Else, Sue Richards, Don Milligan, Terry Hamblin, and Daniel Catovsky, for the UK National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group and NCRI CLL Working Group Blood 2008 111: 1820-1826. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-07-101303 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993) Anthony H. Goldstone, Susan M. Richards, Hillard M. Lazarus, Martin S. Tallman, Georgina Buck, Adele K. Fielding, Alan K. Burnett, Raj Chopra, Peter H. Wiernik, Letizia Foroni, Elisabeth Paietta, Mark R. Litzow, David I. Marks, Jill Durrant, Andrew McMillan, Ian M. Franklin, Selina Luger, Niculae Ciobanu, and Jacob M. Rowe Blood 2008 111: 1827-1833. Prepublished online November 29, 2007; DOI 10.1182/blood-2007-10-116582 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia Philipp le Coutre, Oliver G. Ottmann, Francis Giles, Dong-Wook Kim, Jorge Cortes, Norbert Gattermann, Jane F. Apperley, Richard A. Larson, Elisabetta Abruzzese, Stephen G. O'Brien, Kazimierz Kuliczkowski, Andreas Hochhaus, Francois-Xavier Mahon, Giuseppe Saglio, Marco Gobbi, Yok-Lam Kwong, Michele Baccarani, Timothy Hughes, Giovanni Martinelli, Jerald P. Radich, Ming Zheng, Yaping Shou, and Hagop Kantarjian Blood 2008 111: 1834-1839. Prepublished online November 29, 2007; DOI 10.1182/blood-2007-04-083196 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria Robert A. Brodsky, Neal S. Young, Elisabetta Antonioli, Antonio M. Risitano, Hubert Schrezenmeier, Jörg Schubert, Anna Gaya, Luke Coyle, Carlos de Castro, Chieh-Lin Fu, Jaroslaw P. Maciejewski, Monica Bessler, Henk-André Kroon, Russell P. Rother, and Peter Hillmen Blood 2008 111: 1840-1847. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-06-094136 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies Nancy L. Bartlett, Anas Younes, Matthew H. Carabasi, Andres Forero, Joseph D. Rosenblatt, John P. Leonard, Steven H. Bernstein, R. Gregory Bociek, Jennie M. Lorenz, Bruce W. Hart, and Jeremy Barton Blood 2008 111: 1848-1854. Prepublished online December 13, 2007; DOI 10.1182/blood-2007-07-099317 [Abstract] [Full Text] [PDF]   MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients Hannes Wandt, Ulrike Schäkel, Frank Kroschinsky, Gabriele Prange-Krex, Brigitte Mohr, Christian Thiede, Ulrich Pascheberg, Silke Soucek, Markus Schaich, and Gerhard Ehninger Blood 2008 111: 1855-1861. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-08-101162 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Brief report  Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis Claudia Vener, Nicola Stefano Fracchiolla, Umberto Gianelli, Rossella Calori, Franca Radaelli, Alessandra Iurlo, Sabrina Caberlon, Giancarla Gerli, Leonardo Boiocchi, and Giorgio Lambertenghi Deliliers Blood 2008 111: 1862-1865. Prepublished online November 20, 2007; DOI 10.1182/blood-2007-09-112953 [Abstract] [Full Text] [PDF]   GENE THERAPY: An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation Byoung Y. Ryu, Marguerite V. Evans-Galea, John T. Gray, David M. Bodine, Derek A. Persons, and Arthur W. Nienhuis Blood 2008 111: 1866-1875. Prepublished online November 8, 2007; DOI 10.1182/blood-2007-04-085506 [Abstract] [Full Text] [PDF] [Supplemental Methods, Tables, and Figures]   HEMATOPOIESIS: Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak–like cells and enables isolation of primitive hematopoietic precursors Richard P. Davis, Elizabeth S. Ng, Magdaline Costa, Anna K. Mossman, Koula Sourris, Andrew G. Elefanty, and Edouard G. Stanley Blood 2008 111: 1876-1884. Prepublished online November 21, 2007; DOI 10.1182/blood-2007-06-093609 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications Kathleen Freson, Karen Peeters, Rita De Vos, Christine Wittevrongel, Chantal Thys, Marc F. Hoylaerts, Jos Vermylen, and Chris Van Geet Blood 2008 111: 1885-1893. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-06-098558 [Abstract] [Full Text] [PDF] [Supplemental Figure]   The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress Deidre Daria, Marie-Dominique Filippi, Erik S. Knudsen, Roberta Faccio, Zhixiong Li, Theodosia Kalfa, and Hartmut Geiger Blood 2008 111: 1894-1902. Prepublished online November 29, 2007; DOI 10.1182/blood-2007-02-071746 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Interleukin-27 directly induces differentiation in hematopoietic stem cells Jun Seita, Masayuki Asakawa, Jun Ooehara, Shin-ichiro Takayanagi, Yohei Morita, Nobukazu Watanabe, Koji Fujita, Motoshige Kudo, Junichiro Mizuguchi, Hideo Ema, Hiromitsu Nakauchi, and Takayuki Yoshimoto Blood 2008 111: 1903-1912. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-093328 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Aberrant activation of stress-response pathways leads to TNF- oversecretion in Fanconi anemia Delphine Briot, Gaëtane Macé-Aimé, Frédéric Subra, and Filippo Rosselli Blood 2008 111: 1913-1923. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-07-099218 [Abstract] [Full Text] [PDF]   Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation Daijiro Sugiyama, Makoto Tanaka, Kenji Kitajima, Jie Zheng, Hilo Yen, Tomotaka Murotani, Atsushi Yamatodani, and Toru Nakano Blood 2008 111: 1924-1932. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-08-104489 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells Pengbo Zhang, Jian Li, Zhijia Tan, Chengyan Wang, Ting Liu, Lin Chen, Jun Yong, Wei Jiang, Xiaomeng Sun, Liying Du, Mingxiao Ding, and Hongkui Deng Blood 2008 111: 1933-1941. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-02-074120 [Abstract] [Full Text] [PDF]   Brief report  The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse Prafullakumar Tailor, Tomohiko Tamura, Herbert C. Morse, III, and Keiko Ozato Blood 2008 111: 1942-1945. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-07-100750 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Brief report  Hls5 regulated erythroid differentiation by modulating GATA-1 activity Raelene Endersby, Ian J. Majewski, Louise Winteringham, Jennifer G. Beaumont, Amy Samuels, Robin Scaife, Esther Lim, Merlin Crossley, S. Peter Klinken, and Jean-Philippe Lalonde Blood 2008 111: 1946-1950. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-04-085746 [Abstract] [Full Text] [PDF]   HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY: The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death Isabelle Petit, Matthias A. Karajannis, Loic Vincent, Lauren Young, Jason Butler, Andrea T. Hooper, Koji Shido, Hermann Steller, David J. Chaplin, Eric Feldman, and Shahin Rafii Blood 2008 111: 1951-1961. Prepublished online November 16, 2007; DOI 10.1182/blood-2007-05-089219 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI Manojkumar Valiyaveettil, Niladri Kar, Mohammad Z. Ashraf, Tatiana V. Byzova, Maria Febbraio, and Eugene A. Podrez Blood 2008 111: 1962-1971. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-08-107813 [Abstract] [Full Text] [PDF]   The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2 Norihito Kawasaki, Yoko Ichikawa, Ichiro Matsuo, Kiichiro Totani, Naoki Matsumoto, Yukishige Ito, and Kazuo Yamamoto Blood 2008 111: 1972-1979. Prepublished online December 3, 2007; DOI 10.1182/blood-2007-06-097022 [Abstract] [Full Text] [PDF]   2β1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell–specific manner Zhonghua Zhang, Norma E. Ramirez, Thomas E. Yankeelov, Zhengzhi Li, Laura E. Ford, Ying Qi, Ambra Pozzi, and Mary M. Zutter Blood 2008 111: 1980-1988. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-094680 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow Hendra Setiadi and Rodger P. McEver Blood 2008 111: 1989-1998. Prepublished online November 20, 2007; DOI 10.1182/blood-2007-09-113423 [Abstract] [Full Text] [PDF]   Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature Bi-Sen Ding, Nankang Hong, Juan-Carlos Murciano, Kumkum Ganguly, Claudia Gottstein, Melpo Christofidou-Solomidou, Steven M. Albelda, Aron B. Fisher, Douglas B. Cines, and Vladimir R. Muzykantov Blood 2008 111: 1999-2006. Prepublished online November 28, 2007; DOI 10.1182/blood-2007-07-103002 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito Shigeto Yoshida, Toshiki Sudo, Masashi Niimi, Lian Tao, Bing Sun, Junichi Kambayashi, Hiroyuki Watanabe, Enjie Luo, and Hiroyuki Matsuoka Blood 2008 111: 2007-2014. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-06-097824 [Abstract] [Full Text] [PDF] [Supplemental Figure]   B-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis Anna Dimberg, Svetlana Rylova, Lothar C. Dieterich, Anna-Karin Olsson, Petter Schiller, Charlotte Wikner, Svante Bohman, Johan Botling, Agneta Lukinius, Eric F. Wawrousek, and Lena Claesson-Welsh Blood 2008 111: 2015-2023. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-04-087841 [Abstract] [Full Text] [PDF] [Supplemental Figures]   A2B adenosine receptor dampens hypoxia-induced vascular leak Tobias Eckle, Marion Faigle, Almut Grenz, Stefanie Laucher, Linda F. Thompson, and Holger K. Eltzschig Blood 2008 111: 2024-2035. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-10-117044 [Abstract] [Full Text] [PDF]   Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity Eric Sulpice, Jean Plouët, Mathieu Bergé, David Allanic, Gérard Tobelem, and Tatyana Merkulova-Rainon Blood 2008 111: 2036-2045. Prepublished online December 7, 2007; DOI 10.1182/blood-2007-04-084269 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Brief report  Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia Anna G. McDonald, Katie Yang, Harold R. Roberts, Dougald M. Monroe, and Maureane Hoffman Blood 2008 111: 2046-2048. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-05-092916 [Abstract] [Full Text] [PDF]   Brief report  X-ray crystal structure of the fibrinolysis inhibitor 2-antiplasmin Ruby H. P. Law, Trifina Sofian, Wan-Ting Kan, Anita J. Horvath, Corinne R. Hitchen, Christopher G. Langendorf, Ashley M. Buckle, James C. Whisstock, and Paul B. Coughlin Blood 2008 111: 2049-2052. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-09-114215 [Abstract] [Full Text] [PDF] [Supplemental Figure]   IMMUNOBIOLOGY: CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals Laura Crompton, Naeem Khan, Rajiv Khanna, Laxman Nayak, and Paul A. H. Moss Blood 2008 111: 2053-2061. Prepublished online November 6, 2007; DOI 10.1182/blood-2007-04-079863 [Abstract] [Full Text] [PDF]   STAT1 signaling modulates HIV-1–induced inflammatory responses and leukocyte transmigration across the blood-brain barrier Anathbandhu Chaudhuri, Bo Yang, Howard E. Gendelman, Yuri Persidsky, and Georgette D. Kanmogne Blood 2008 111: 2062-2072. Prepublished online November 14, 2007; DOI 10.1182/blood-2007-05-091207 [Abstract] [Full Text] [PDF]   In vivo transformation of mouse conventional CD8+ dendritic cells leads to progressive multisystem histiocytosis Quynh-Giao Steiner, Luc A. Otten, M. John Hicks, Gürkan Kaya, Frederic Grosjean, Estelle Saeuberli, Christine Lavanchy, Friedrich Beermann, Kenneth L. McClain, and Hans Acha-Orbea Blood 2008 111: 2073-2082. Prepublished online November 20, 2007; DOI 10.1182/blood-2007-06-097576 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development Christina T. Jensen, Charlotta Böiers, Shabnam Kharazi, Anna Lübking, Tobias Rydén, Mikael Sigvardsson, Ewa Sitnicka, and Sten Eirik W. Jacobsen Blood 2008 111: 2083-2090. Prepublished online November 26, 2007; DOI 10.1182/blood-2007-08-108563 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figure]   Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses Tony J. Kenna, Ranjeny Thomas, and Raymond J. Steptoe Blood 2008 111: 2091-2100. Prepublished online November 14, 2007; DOI 10.1182/blood-2007-07-103200 [Abstract] [Full Text] [PDF]   IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival Jessica A. Wofford, Heather L. Wieman, Sarah R. Jacobs, Yuxing Zhao, and Jeffrey C. Rathmell Blood 2008 111: 2101-2111. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-096297 [Abstract] [Full Text] [PDF]   Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation Paria Mirmonsef, Gladys Tan, Gang Zhou, Tricia Morino, Kimberly Noonan, Ivan Borrello, and Hyam I. Levitsky Blood 2008 111: 2112-2121. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-06-096586 [Abstract] [Full Text] [PDF]   Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria Pierre Tissières, Irène Dunn-Siegrist, Michela Schäppi, Greg Elson, Rachel Comte, Vandack Nobre, and Jérôme Pugin Blood 2008 111: 2122-2131. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-06-097782 [Abstract] [Full Text] [PDF]   Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients Megumu Saito, Ryuta Nishikomori, Naotomo Kambe, Akihiro Fujisawa, Hideaki Tanizaki, Kyoko Takeichi, Tomoyuki Imagawa, Tomoko Iehara, Hidetoshi Takada, Tadashi Matsubayashi, Hiroshi Tanaka, Hisashi Kawashima, Kiyoshi Kawakami, Shinji Kagami, Ikuo Okafuji, Takakazu Yoshioka, Souichi Adachi, Toshio Heike, Yoshiki Miyachi, and Tatsutoshi Nakahata Blood 2008 111: 2132-2141. Prepublished online December 6, 2007; DOI 10.1182/blood-2007-06-094201 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise Ing Swie Goping, Tracy Sawchuk, Aja Rieger, Irene Shostak, and R. Chris Bleackley Blood 2008 111: 2142-2151. Prepublished online December 20, 2007; DOI 10.1182/blood-2007-08-105221 [Abstract] [Full Text] [PDF]   Brief report  Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells Stefan Lob, Alfred Konigsrainer, Richard Schafer, Hans-Georg Rammensee, Gerhard Opelz, and Peter Terness Blood 2008 111: 2152-2154. Prepublished online November 28, 2007; DOI 10.1182/blood-2007-10-116111 [Abstract] [Full Text] [PDF]   Brief report  The specificity of JAK3 kinase inhibitors Paul S. Changelian, Deborah Moshinsky, Cyrille F. Kuhn, Mark E. Flanagan, Michael J. Munchhof, Thomas M. Harris, Jonathan L. Doty, Jianmin Sun, Craig R. Kent, Kelly S. Magnuson, David G. Perregaux, Perry S. Sawyer, and Elizabeth M. Kudlacz Blood 2008 111: 2155-2157. Prepublished online December 19, 2007; DOI 10.1182/blood-2007-09-115030 [Abstract] [Full Text] [PDF]   Brief report  Requirement for CD1d expression by B cells to stimulate NKT cell–enhanced antibody production Gillian A. Lang, T. Scott Devera, and Mark L. Lang Blood 2008 111: 2158-2162. Prepublished online December 12, 2007; DOI 10.1182/blood-2007-10-117309 [Abstract] [Full Text] [PDF]   NEOPLASIA: Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations Craig H. Bassing, Sheila Ranganath, Mike Murphy, Velibor Savic, Meagan Gleason, and Frederick W. Alt Blood 2008 111: 2163-2169. Prepublished online September 13, 2007; DOI 10.1182/blood-2007-08-104760 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study Simone Boehrer, Lionel Adès, Thorsten Braun, Lorenzo Galluzzi, Jennifer Grosjean, Claire Fabre, Génèviève Le Roux, Claude Gardin, Antoine Martin, Stéphane de Botton, Pierre Fenaux, and Guido Kroemer Blood 2008 111: 2170-2180. Prepublished online October 9, 2007; DOI 10.1182/blood-2007-07-100362 [Abstract] [Full Text] [PDF] [Supplemental Figure]   IL-2– and IL-15–induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes Michal Marzec, Xiaobin Liu, Monika Kasprzycka, Agnieszka Witkiewicz, Puthiyaveettil N. Raghunath, Mouna El-Salem, Erle Robertson, Niels Odum, and Mariusz A. Wasik Blood 2008 111: 2181-2189. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-06-095182 [Abstract] [Full Text] [PDF]   p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death Ondrej Krejci, Mark Wunderlich, Hartmut Geiger, Fu-Sheng Chou, David Schleimer, Michael Jansen, Paul R. Andreassen, and James C. Mulloy Blood 2008 111: 2190-2199. Prepublished online November 1, 2007; DOI 10.1182/blood-2007-06-093682 [Abstract] [Full Text] [PDF]   Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib Matthias Mayerhofer, Karoline V. Gleixner, Julia Mayerhofer, Gregor Hoermann, Eva Jaeger, Karl J. Aichberger, Rene G. Ott, Khaled Greish, Hideaki Nakamura, Sophia Derdak, Puchit Samorapoompichit, Winfried F. Pickl, Veronika Sexl, Harald Esterbauer, Ilse Schwarzinger, Christian Sillaber, Hiroshi Maeda, and Peter Valent Blood 2008 111: 2200-2210. Prepublished online November 16, 2007; DOI 10.1182/blood-2006-11-055723 [Abstract] [Full Text] [PDF]   Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action Zhengxing Qu, David M. Goldenberg, Thomas M. Cardillo, Victoria Shi, Hans J. Hansen, and Chien-Hsing Chang Blood 2008 111: 2211-2219. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-08-110072 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy Yulia Nefedova, Daniel M. Sullivan, Sophia C. Bolick, William S. Dalton, and Dmitry I. Gabrilovich Blood 2008 111: 2220-2229. Prepublished online November 26, 2007; DOI 10.1182/blood-2007-07-102632 [Abstract] [Full Text] [PDF]   SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma Linfeng Chen, Stefano Monti, Przemyslaw Juszczynski, John Daley, Wen Chen, Thomas E. Witzig, Thomas M. Habermann, Jeffery L. Kutok, and Margaret A. Shipp Blood 2008 111: 2230-2237. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-07-100115 [Abstract] [Full Text] [PDF] [Supplemental Methods, Tables and Figure]   RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia Jeffrey W. Tyner, Denise K. Walters, Stephanie G. Willis, Mary Luttropp, Jason Oost, Marc Loriaux, Heidi Erickson, Amie S. Corbin, Thomas O'Hare, Michael C. Heinrich, Michael W. Deininger, and Brian J. Druker Blood 2008 111: 2238-2245. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-06-097253 [Abstract] [Full Text] [PDF] [Supplemental Appendix, Tables, and Figures]   Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia Göran Roos, Alexander Kröber, Pawel Grabowski, Dirk Kienle, Andreas Bühler, Hartmut Döhner, Richard Rosenquist, and Stephan Stilgenbauer Blood 2008 111: 2246-2252. Prepublished online November 28, 2007; DOI 10.1182/blood-2007-05-092759 [Abstract] [Full Text] [PDF]   Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity? Alexandra Traverse-Glehen, Lucile Baseggio, Evelyne Callet- Bauchu, Dominique Morel, Sophie Gazzo, Martine Ffrench, Aurélie Verney, Delphine Rolland, Catherine Thieblemont, Jean-Pierre Magaud, Gilles Salles, Bertrand Coiffier, Françoise Berger, and Pascale Felman Blood 2008 111: 2253-2260. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-07-098848 [Abstract] [Full Text] [PDF]   Eradication of disseminated leukemia in a syngeneic murine leukemia model using pretargeted anti-CD45 radioimmunotherapy John M. Pagel, Nathan Hedin, Lacey Drouet, Brent L. Wood, Anastasia Pantelias, Yukang Lin, Donald K. Hamlin, D. Scott Wilbur, Ajay K. Gopal, Damian Green, Frederick R. Appelbaum, and Oliver W. Press Blood 2008 111: 2261-2268. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-097451 [Abstract] [Full Text] [PDF] [Supplemental Figures]   A critical role for Lyn in acute myeloid leukemia Cédric Dos Santos, Cécile Demur, Valérie Bardet, Nais Prade-Houdellier, Bernard Payrastre, and Christian Récher Blood 2008 111: 2269-2279. Prepublished online December 3, 2007; DOI 10.1182/blood-2007-04-082099 [Abstract] [Full Text] [PDF] [Supplemental Figures]   The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis Dong Yun Lee and Bill Sugden Blood 2008 111: 2280-2289. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-07-100032 [Abstract] [Full Text] [PDF]   Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts Simona Moretti, Antonio Procopio, Raffaella Lazzarini, Maria Rita Rippo, Roberto Testa, Maurizio Marra, Luca Tamagnone, and Alfonso Catalano Blood 2008 111: 2290-2299. Prepublished online December 3, 2007; DOI 10.1182/blood-2007-06-096529 [Abstract] [Full Text] [PDF] [Supplemental Figures]   BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia Victoria Del Gaizo Moore, Krysta D. Schlis, Stephen E. Sallan, Scott A. Armstrong, and Anthony Letai Blood 2008 111: 2300-2309. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-06-098012 [Abstract] [Full Text] [PDF]   Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts Sebastien Tauzin, Heidrun Ding, Karim Khatib, Ishtiaq Ahmad, Dimitri Burdevet, Gerhild van Echten-Deckert, Jonathan A. Lindquist, Burkhart Schraven, Nasir-ud- Din, Bettina Borisch, and Daniel C. Hoessli Blood 2008 111: 2310-2320. Prepublished online December 10, 2007; DOI 10.1182/blood-2007-05-090985 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia Emilie Le Toriellec, Gilles Despouy, Gaëlle Pierron, Nogaye Gaye, Marjorie Joiner, Dorine Bellanger, Anne Vincent-Salomon, and Marc-Henri Stern Blood 2008 111: 2321-2328. Prepublished online December 11, 2007; DOI 10.1182/blood-2007-06-095570 [Abstract] [Full Text] [PDF]   Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606 Heiko Konig, Tessa L. Holyoake, and Ravi Bhatia Blood 2008 111: 2329-2338. Prepublished online December 4, 2007; DOI 10.1182/blood-2007-05-092056 [Abstract] [Full Text] [PDF]   Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes Yue Ma, Lydia Visser, Han Roelofsen, Marcel de Vries, Arjan Diepstra, Gustaaf van Imhoff, Tineke van der Wal, Marjan Luinge, Gloria Alvarez-Llamas, Hans Vos, Sibrand Poppema, Roel Vonk, and Anke van den Berg Blood 2008 111: 2339-2346. Prepublished online December 10, 2007; DOI 10.1182/blood-2007-09-112128 [Abstract] [Full Text] [PDF] [Supplemental Tables]   Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma Andrea J. O'Hara, Wolfgang Vahrson, and Dirk P. Dittmer Blood 2008 111: 2347-2353. Prepublished online December 13, 2007; DOI 10.1182/blood-2007-08-104463 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC1- and Ca2+-dependent apoptosis Sven Baumann, Stefanie C. Fas, Marco Giaisi, Wolfgang W. Müller, Anette Merling, Karsten Gülow, Lutz Edler, Peter H. Krammer, and Min Li-Weber Blood 2008 111: 2354-2363. Prepublished online December 10, 2007; DOI 10.1182/blood-2007-06-096198 [Abstract] [Full Text] [PDF]   Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-B–dependent DNA methyltransferase activity in acute myeloid leukemia Shujun Liu, Zhongfa Liu, Zhiliang Xie, Jiuxia Pang, Jianhua Yu, Esther Lehmann, Lenguyen Huynh, Tamara Vukosavljevic, Mitsui Takeki, Rebecca B. Klisovic, Robert A. Baiocchi, William Blum, Pierluigi Porcu, Ramiro Garzon, John C. Byrd, Danilo Perrotti, Michael A. Caligiuri, Kenneth K. Chan, Lai-Chu Wu, and Guido Marcucci Blood 2008 111: 2364-2373. Prepublished online December 14, 2007; DOI 10.1182/blood-2007-08-110171 [Abstract] [Full Text] [PDF]   Brief report  DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia Annegret Glasow, Angela Barrett, Kevin Petrie, Rajeev Gupta, Manuel Boix-Chornet, Da-Cheng Zhou, David Grimwade, Robert Gallagher, Marieke von Lindern, Samuel Waxman, Tariq Enver, Guido Hildebrandt, and Arthur Zelent Blood 2008 111: 2374-2377. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-05-088344 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Brief report  In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib Jamshid S. Khorashad, Dragana Milojkovic, Puja Mehta, Mona Anand, Sara Ghorashian, Alistair G. Reid, Valeria De Melo, Anna Babb, Hugues de Lavallade, Eduardo Olavarria, David Marin, John M. Goldman, Jane F. Apperley, and Jaspal S. Kaeda Blood 2008 111: 2378-2381. Prepublished online November 2, 2007; DOI 10.1182/blood-2007-06-096396 [Abstract] [Full Text] [PDF]   Brief report  Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia Yasuhiro Oki, Jaroslav Jelinek, Lanlan Shen, Hagop M. Kantarjian, and Jean-Pierre J. Issa Blood 2008 111: 2382-2384. Prepublished online November 30, 2007; DOI 10.1182/blood-2007-07-103960 [Abstract] [Full Text] [PDF]   Brief report  Ki-67 predicts outcome in advanced-stage mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: results from randomized trials of the European MCL Network and the German Low Grade Lymphoma Study Group Olaf Determann, Eva Hoster, German Ott, Heinz Wolfram Bernd, Christoph Loddenkemper, Martin Leo Hansmann, Thomas E. F. Barth, Michael Unterhalt, Wolfgang Hiddemann, Martin Dreyling, and Wolfram Klapper, for the European Mantle Cell Lymphoma Network and the German Low Grade Lymphoma Study Group Blood 2008 111: 2385-2387. Prepublished online December 12, 2007; DOI 10.1182/blood-2007-10-117010 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Brief report  Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia Delphine Poncet, Aurélie Belleville, Claire t'Kint de Roodenbeke, Aude Roborel de Climens, Elsa Ben Simon, Hélène Merle-Beral, Evelyne Callet-Bauchu, Gilles Salles, Laure Sabatier, Jozo Delic, and Eric Gilson Blood 2008 111: 2388-2391. Prepublished online December 12, 2007; DOI 10.1182/blood-2007-09-111245 [Abstract] [Full Text] [PDF]   PHAGOCYTES: Autocrine formation of hepcidin induces iron retention in human monocytes Igor Theurl, Milan Theurl, Markus Seifert, Sabine Mair, Manfred Nairz, Holger Rumpold, Heinz Zoller, Rosa Bellmann-Weiler, Harald Niederegger, Heribert Talasz, and Günter Weiss Blood 2008 111: 2392-2399. Prepublished online December 11, 2007; DOI 10.1182/blood-2007-05-090019 [Abstract] [Full Text] [PDF]   RED CELLS: Globin switches in yolk sac–like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells Caihong Qiu, Emmanuel N. Olivier, Michelle Velho, and Eric E. Bouhassira Blood 2008 111: 2400-2408. Prepublished online November 16, 2007; DOI 10.1182/blood-2007-07-102087 [Abstract] [Full Text] [PDF]   Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus Kathleen E. McGrath, Paul D. Kingsley, Anne D. Koniski, Rebecca L. Porter, Timothy P. Bushnell, and James Palis Blood 2008 111: 2409-2417. Prepublished online November 21, 2007; DOI 10.1182/blood-2007-08-107581 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Maurer's clefts of Plasmodium falciparum are secretory organelles that concentrate virulence protein reporters for delivery to the host erythrocyte Souvik Bhattacharjee, Christiaan van Ooij, Bharath Balu, John H. Adams, and Kasturi Haldar Blood 2008 111: 2418-2426. Prepublished online December 5, 2007; DOI 10.1182/blood-2007-09-115279 [Abstract] [Full Text] [PDF] [Supplemental Figures]   STEM CELLS IN HEMATOLOGY: Hematopoietic origin of hepatic stellate cells in the adult liver Eri Miyata, Masahiro Masuya, Shuro Yoshida, Shiho Nakamura, Keizo Kato, Yuka Sugimoto, Tetsunori Shibasaki, Kentaro Yamamura, Kohshi Ohishi, Kazuhiro Nishii, Fumihiko Ishikawa, Hiroshi Shiku, and Naoyuki Katayama Blood 2008 111: 2427-2435. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-07-101261 [Abstract] [Full Text] [PDF]