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About the Cover for Blood 111 (12)
The structure of the N-terminal region of alpha-spectrin. See the related article by Gaetani et al beginning on page 5712. They measure the effects of some common mutations associated with hereditary elliptocytosis, including residues I24, R28, and R45 in the first alpha-helix, which can entirely abolish interaction with beta-spectrin. The image was drawn from Protein Databank entry 1OWA (Park S, Caffrey MS, Johnson ME, Fung LW. Solution structural studies on human erythrocyte alpha-spectrin tetramerization site. J Biol Chem. 2003;278:21837-21844.) by Anthony Baines and Debra Tyler. [Table of Contents] |
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| Copyright © 2008 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||||
