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Receive this page by email each issue: [Sign up for eTOCs] Other Issues: December 1 2006; 108 (12)   [Index by Author]  [Cover Caption] [Complete Inside Blood PDF]        INSIDE BLOOD        BLOOD WORK        PLENARY PAPERS        REVIEW IN TRANSLATIONAL HEMATOLOGY        CLINICAL TRIALS AND OBSERVATIONS        HEMATOPOIESIS        HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY        IMMUNOBIOLOGY        NEOPLASIA        PHAGOCYTES        STEM CELLS IN HEMATOLOGY        TRANSPLANTATION        CORRESPONDENCE Find articles in this issue containing these words: [Search ALL Issues] Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Advertising (PDF) To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. INSIDE BLOOD: "Quick" fix to add to the mix? Mervin C. Yoder Blood 2006 108: 3625-3626. [Full Text] [PDF]   MSCs roll into the mainstream Darwin J. Prockop Blood 2006 108: 3626-3627. [Full Text] [PDF]   Sticky business: von Willebrand factor in inflammation José A. López Blood 2006 108: 3627. [Full Text] [PDF]   When collagen meets VWF Hans Deckmyn and Karen Vanhoorelbeke Blood 2006 108: 3628. [Full Text] [PDF]   The thymus: a house dividing Geoffrey O. Gillard and Andrew G. Farr Blood 2006 108: 3629-3630. [Full Text] [PDF]   Hodgkin lymphoma: to the HAART of the matter Alexandra M. Levine Blood 2006 108: 3630. [Full Text] [PDF]   It's hepcidin again, but is it the only master? Prem Ponka and Alex D. Sheftel Blood 2006 108: 3631-3632. [Full Text] [PDF]   Refining therapy for AL amyloidosis Giampaolo Merlini Blood 2006 108: 3632-3633. [Full Text] [PDF]   A new Rac-ket in red cells Velia M. Fowler and Robert S. Fischer Blood 2006 108: 3633-3634. [Full Text] [PDF]   A TRAIL to Chinese herbal medicine Peter T. Daniel Blood 2006 108: 3634. [Full Text] [PDF]   BLOOD WORK: Anemia and splenomegaly Blood 2006 108: 3635. [Full Text] [PDF]   PLENARY PAPERS: Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton Theodosia A. Kalfa, Suvarnamala Pushkaran, Narla Mohandas, John H. Hartwig, Velia M. Fowler, James F. Johnson, Clinton H. Joiner, David A. Williams, and Yi Zheng Blood 2006 108: 3637-3645. Prepublished online August 1, 2006; DOI 10.1182/blood-2006-03-005942 [Abstract] [Full Text] [PDF]   REVIEW IN TRANSLATIONAL HEMATOLOGY: MicroRNAs: regulators of gene expression and cell differentiation Ramesh A. Shivdasani Blood 2006 108: 3646-3653. Prepublished online August 1, 2006; DOI 10.1182/blood-2006-01-030015 [Abstract] [Full Text] [PDF]   CLINICAL TRIALS AND OBSERVATIONS: Clinical implications of FLT3 mutations in pediatric AML Soheil Meshinchi, Todd A. Alonzo, Derek L. Stirewalt, Michel Zwaan, Martin Zimmerman, Dirk Reinhardt, Gertjan J. L. Kaspers, Nyla A. Heerema, Robert Gerbing, Beverly J. Lange, and Jerald P. Radich Blood 2006 108: 3654-3661. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-03-009233 [Abstract] [Full Text] [PDF]   Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100 Rebecca M. Shepherd, Benjamin J. Capoccia, Steven M. Devine, John DiPersio, Kathryn M. Trinkaus, David Ingram, and Daniel C. Link Blood 2006 108: 3662-3667. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-06-030577 [Abstract] [Full Text] [PDF]   Prolonged bleeding-free period following prophylactic infusion of recombinant factor VIII reconstituted with pegylated liposomes Jack Spira, Olga P. Plyushch, Tatyana A. Andreeva, and Yury Andreev Blood 2006 108: 3668-3673. Prepublished online August 3, 2006; DOI 10.1182/blood-2006-03-008276 [Abstract] [Full Text] [PDF]   Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics Daniel J. DeAngelo, Richard M. Stone, Mark L. Heaney, Stephen D. Nimer, Ronald L. Paquette, Rebecca B. Klisovic, Michael A. Caligiuri, Michael R. Cooper, Jean-Michel Lecerf, Michael D. Karol, Shihong Sheng, Nick Holford, Peter T. Curtin, Brian J. Druker, and Michael C. Heinrich Blood 2006 108: 3674-3681. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-02-005702 [Abstract] [Full Text] [PDF]   HEMATOPOIESIS: STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils Athanasia D. Panopoulos, Ling Zhang, Jonathan W. Snow, Daniel M. Jones, Amber M. Smith, Karim C. El Kasmi, Fulu Liu, Mark A. Goldsmith, Daniel C. Link, Peter J. Murray, and Stephanie S. Watowich Blood 2006 108: 3682-3690. Prepublished online August 3, 2006; DOI 10.1182/blood-2006-02-003012 [Abstract] [Full Text] [PDF]   Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells Allen K. L. Cheung, Allison Abendroth, Anthony L. Cunningham, and Barry Slobedman Blood 2006 108: 3691-3699. Prepublished online August 24, 2006; DOI 10.1182/blood-2005-12-026682 [Abstract] [Full Text] [PDF] [Supplemental Table]   Wogonin sensitizes resistant malignant cells to TNF- and TRAIL-induced apoptosis Stefanie C. Fas, Sven Baumann, Jia Yun Zhu, Marco Giaisi, Monika K. Treiber, Ulrich Mahlknecht, Peter H. Krammer, and Min Li-Weber Blood 2006 108: 3700-3706. Prepublished online August 24, 2006; DOI 10.1182/blood-2006-03-011973 [Abstract] [Full Text] [PDF]   Smad5 is dispensable for adult murine hematopoiesis Sofie Singbrant, Jennifer L. Moody, Ulrika Blank, Goran Karlsson, Lieve Umans, An Zwijsen, and Stefan Karlsson Blood 2006 108: 3707-3712. Prepublished online August 8, 2006; DOI 10.1182/blood-2006-02-003384 [Abstract] [Full Text] [PDF]   Growth factor receptors as regulators of hematopoiesis Michael A. Weinreich, Ingrid Lintmaer, Linlin Wang, H. Denny Liggitt, Michael A. Harkey, and C. Anthony Blau Blood 2006 108: 3713-3721. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-01-012278 [Abstract] [Full Text] [PDF]   CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes Antonia Wimmer, Sophia K. Khaldoyanidi, Martin Judex, Naira Serobyan, Richard G. DiScipio, and Ingrid U. Schraufstatter Blood 2006 108: 3722-3729. Prepublished online August 3, 2006; DOI 10.1182/blood-2006-04-014399 [Abstract] [Full Text] [PDF] [Supplemental Table]   Suppression of hepcidin during anemia requires erythropoietic activity Mihwa Pak, Miguel A. Lopez, Victroia Gabayan, Tomas Ganz, and Seth Rivera Blood 2006 108: 3730-3735. Prepublished online August 1, 2006; DOI 10.1182/blood-2006-06-028787 [Abstract] [Full Text] [PDF]   Brief report  Acetylation of GATA-1 is required for chromatin occupancy Janine M. Lamonica, Christopher R. Vakoc, and Gerd A. Blobel Blood 2006 108: 3736-3738. Prepublished online August 3, 2006; DOI 10.1182/blood-2006-07-032847 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figures]   HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY: Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A Jan Astermark, Johannes Oldenburg, Joyce Carlson, Anna Pavlova, Kaan Kavakli, Erik Berntorp, and Ann-Kari Lefvert, for the MIBS Study Group Blood 2006 108: 3739-3745. Prepublished online August 22, 2006; DOI 10.1182/blood-2006-05-024711 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   P-selectin glycoprotein ligand 1 and 2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor Ronan Pendu, Virginie Terraube, Olivier D. Christophe, Carl G. Gahmberg, Philip G. de Groot, Peter J. Lenting, and Cecile V. Denis Blood 2006 108: 3746-3752. Prepublished online August 22, 2006; DOI 10.1182/blood-2006-03-010322 [Abstract] [Full Text] [PDF] [Supplemental Videos]   Brief report  A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides Ton Lisman, Nicolas Raynal, Dafna Groeneveld, Ben Maddox, Anthony R. Peachey, Eric G. Huizinga, Philip G. de Groot, and Richard W. Farndale Blood 2006 108: 3753-3756. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-03-011965 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figure]   Brief report  siRNA silencing of calumenin enhances functional factor IX production Nadeem Wajih, Susan M. Hutson, and Reidar Wallin Blood 2006 108: 3757-3760. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-02-004671 [Abstract] [Full Text] [PDF]   IMMUNOBIOLOGY: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes Annika Grabbe and Jürgen Wienands Blood 2006 108: 3761-3768. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-02-005397 [Abstract] [Full Text] [PDF]   c-Rel plays a key role in deficient activation of B cells from a non–X-linked hyper-IgM patient Kristina T. Lu, Frank L. Sinquett, Rebecca L. Dryer, Charles Song, and Lori R. Covey Blood 2006 108: 3769-3776. Prepublished online August 8, 2006; DOI 10.1182/blood-2006-03-008839 [Abstract] [Full Text] [PDF]   Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells Daniel H. D. Gray, Natalie Seach, Tomoo Ueno, Morag K. Milton, Adrian Liston, Andrew M. Lew, Christopher C. Goodnow, and Richard L. Boyd Blood 2006 108: 3777-3785. Prepublished online August 8, 2006; DOI 10.1182/blood-2006-02-004531 [Abstract] [Full Text] [PDF]   Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS Robert J. Biggar, Elaine S. Jaffe, James J. Goedert, Anil Chaturvedi, Ruth Pfeiffer, and Eric A. Engels, for the HIV/AIDS Cancer Match Study Blood 2006 108: 3786-3791. Prepublished online August 17, 2006; DOI 10.1182/blood-2006-05-024109 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Stimulated plasmacytoid dendritic cells impair human T-cell development Heike Schmidlin, Wendy Dontje, Fedde Groot, Suzanne J. Ligthart, Arnaud D. Colantonio, Monique E. Oud, Esther J. Schilder-Tol, Marcel Spaargaren, Hergen Spits, Christel H. Uittenbogaart, and Bianca Blom Blood 2006 108: 3792-3800. Prepublished online August 17, 2006; DOI 10.1182/blood-2006-02-004978 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection Angelina Jane Mosley, Kiran N. Meekings, Corinna McCarthy, Dawn Shepherd, Vincenzo Cerundolo, Ralph Mazitschek, Yuetsu Tanaka, Graham P. Taylor, and Charles R. Bangham Blood 2006 108: 3801-3807. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-03-013235 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   HIV-1–driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS Jakob Nilsson, Adriano Boasso, Paula Andrea Velilla, Rui Zhang, Monica Vaccari, Genoveffa Franchini, Gene M. Shearer, Jan Andersson, and Claire Chougnet Blood 2006 108: 3808-3817. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-05-021576 [Abstract] [Full Text] [PDF]   CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent Luca Gattinoni, Anju Ranganathan, Deborah R. Surman, Douglas C. Palmer, Paul A. Antony, Marc R. Theoret, David M. Heimann, Steven A. Rosenberg, and Nicholas P. Restifo Blood 2006 108: 3818-3823. Prepublished online August 1, 2006; DOI 10.1182/blood-2006-07-034066 [Abstract] [Full Text] [PDF]   Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells Bartosz Grzywacz, Nandini Kataria, Magdalena Sikora, Robert A. Oostendorp, Elaine A. Dzierzak, Bruce R. Blazar, Jeffrey S. Miller, and Michael R. Verneris Blood 2006 108: 3824-3833. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-04-020198 [Abstract] [Full Text] [PDF]   CTLA-4 blockade decreases TGF-, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques Anna Hryniewicz, Adriano Boasso, Yvette Edghill-Smith, Monica Vaccari, Dietmar Fuchs, David Venzon, Janos Nacsa, Michael R. Betts, Wen-Po Tsai, Jean-Michel Heraud, Brigitte Beer, Diann Blanset, Claire Chougnet, Israel Lowy, Gene M. Shearer, and Genoveffa Franchini Blood 2006 108: 3834-3842. Prepublished online August 8, 2006; DOI 10.1182/blood-2006-04-010637 [Abstract] [Full Text] [PDF]   Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia Daniela Montagna, Rita Maccario, Franco Locatelli, Enrica Montini, Sara Pagani, Federico Bonetti, Liane Daudt, Ilaria Turin, Daniela Lisini, Claudio Garavaglia, Paolo Dellabona, and Giulia Casorati Blood 2006 108: 3843-3850. Prepublished online July 25, 2006; DOI 10.1182/blood-2006-05-021535 [Abstract] [Full Text] [PDF]   Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses Mariella Della Chiesa, Chiara Romagnani, Andreas Thiel, Lorenzo Moretta, and Alessandro Moretta Blood 2006 108: 3851-3858. Prepublished online July 27, 2006; DOI 10.1182/blood-2006-02-004028 [Abstract] [Full Text] [PDF]   Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth Stephanie Tobollik, Linda Meyer, Maike Buettner, Sandra Klemmer, Bettina Kempkes, Elisabeth Kremmer, Gerald Niedobitek, and Berit Jungnickel Blood 2006 108: 3859-3864. Prepublished online August 1, 2006; DOI 10.1182/blood-2006-05-021303 [Abstract] [Full Text] [PDF]   Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide Katja Mauerer Zirlik, David Zahrieh, Donna Neuberg, and John G. Gribben Blood 2006 108: 3865-3870. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-04-014415 [Abstract] [Full Text] [PDF]   Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma Marion Lambert, Monique Gannagé, Alexandre Karras, Michal Abel, Christophe Legendre, Delphine Kerob, Felix Agbalika, Pierre-Marie Girard, Celeste Lebbe, and Sophie Caillat-Zucman Blood 2006 108: 3871-3880. Prepublished online August 22, 2006; DOI 10.1182/blood-2006-03-014225 [Abstract] [Full Text] [PDF] [Supplemental Table]   NEOPLASIA: ABCG2 expression, function, and promoter methylation in human multiple myeloma Joel G. Turner, Jana L. Gump, Chunchun Zhang, James M. Cook, Douglas Marchion, Lori Hazlehurst, Pamela Munster, Michael J. Schell, William S. Dalton, and Daniel M. Sullivan Blood 2006 108: 3881-3889. Prepublished online August 17, 2006; DOI 10.1182/blood-2005-10-009084 [Abstract] [Full Text] [PDF]   T lymphocytes redirected against the light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells Juan Vera, Barbara Savoldo, Stephane Vigouroux, Ettore Biagi, Martin Pule, Claudia Rossig, Jessie Wu, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, and Gianpietro Dotti Blood 2006 108: 3890-3897. Prepublished online August 22, 2006; DOI 10.1182/blood-2006-04-017061 [Abstract] [Full Text] [PDF] [Supplemental Figure]   High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics Michael Heuser, Gernot Beutel, Juergen Krauter, Konstanze Döhner, Nils von Neuhoff, Brigitte Schlegelberger, and Arnold Ganser Blood 2006 108: 3898-3905. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-04-014845 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Characterization of stem cell–like cancer cells in immune-competent mice Jorg A. Kruger, Charles D. Kaplan, Yunping Luo, He Zhou, Dorothy Markowitz, Rong Xiang, and Ralph A. Reisfeld Blood 2006 108: 3906-3912. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-05-024687 [Abstract] [Full Text] [PDF]   Brief report  Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression Alison R. Moliterno, Donna M. Williams, Ophelia Rogers, and Jerry L. Spivak Blood 2006 108: 3913-3915. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-03-008805 [Abstract] [Full Text] [PDF]   Brief report  Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia Mays Jawad, Claire Helen Seedhouse, Nigel Russell, and Mark Plumb Blood 2006 108: 3916-3918. Prepublished online August 10, 2006; DOI 10.1182/blood-2006-05-022921 [Abstract] [Full Text] [PDF]   PHAGOCYTES: The Vav binding site of the non–receptor tyrosine kinase Syk at Tyr 348 is critical for 2 integrin (CD11/CD18)–mediated neutrophil migration Jurgen Schymeinsky, Anca Sindrilaru, David Frommhold, Markus Sperandio, Ronald Gerstl, Cornelia Then, Attila Mócsai, Karin Scharffetter-Kochanek, and Barbara Walzog Blood 2006 108: 3919-3927. Prepublished online August 1, 2006; DOI 10.1182/blood-2005-12-030387 [Abstract] [Full Text] [PDF] [Supplemental Videos and Figures]   STEM CELLS IN HEMATOLOGY: SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade Oscar M. Pello, María del Carmen Moreno-Ortiz, José Miguel Rodríguez-Frade, Laura Martínez-Muñoz, Daniel Lucas, Lucio Gómez, Pilar Lucas, Enrique Samper, Miguel Aracil, Carlos Martínez-A, Antonio Bernad, and Mario Mellado Blood 2006 108: 3928-3937. Prepublished online August 15, 2006; DOI 10.1182/blood-2006-02-006353 [Abstract] [Full Text] [PDF] [Supplemental Figures]   TRANSPLANTATION: Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells Brigitte Rüster, Stephan Göttig, Ralf J. Ludwig, Roxana Bistrian, Stefanie Müller, Erhard Seifried, Jens Gille, and Reinhard Henschler Blood 2006 108: 3938-3944. Prepublished online August 8, 2006; DOI 10.1182/blood-2006-05-025098 [Abstract] [Full Text] [PDF] [Supplemental Video]   Brief report  Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65 David C. Seldin, Jennifer J. Anderson, Martha Skinner, Karim Malek, Daniel G. Wright, Karen Quillen, Kathleen Finn, Betul Oran, and Vaishali Sanchorawala Blood 2006 108: 3945-3947. Prepublished online August 22, 2006; DOI 10.1182/blood-2006-06-029728 [Abstract] [Full Text] [PDF]   CORRESPONDENCE: Chromosomal abnormalities in marrow stromal cells from myelodysplastic syndromes (MDS) Eugenia Flores-Figueroa, Hector Mayani, Aravind Ramakrishnan, and Beverly Torok-Storb Blood 2006 108: 3948-3949. [Full Text] [PDF]   Discrete stem cells: subsets or a continuum? Mark A. Kirkland, Peter J. Quesenberry, Ingo Roeder, Hans Sieburg, Rebecca Cho, Bradley Dykstra, Naoyuki Uchida, Connie Eaves, and Christa Muller-Sieburg Blood 2006 108: 3949-3950. [Full Text] [PDF]   Increased mortality with FLA compared with ADE chemotherapy in high-risk AML Steven W. Lane, Paula Marlton, Peter N. Mollee, Donald W. Milligan, Alan K. Burnett, and Keith Wheatley Blood 2006 108: 3950-3951. [Full Text] [PDF]   Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone Patrizia Tosi, Elena Zamagni, Delia Cangini, Paola Tacchetti, Francesco Di Raimondo, Lucio Catalano, Alfonso D'Arco, Sonia Ronconi, Claudia Cellini, Massimo Offidani, Giulia Perrone, Michela Ceccolini, Annamaria Brioli, Sante Tura, Michele Baccarani, and Michele Cavo Blood 2006 108: 3951-3952. [Full Text] [PDF]   Use of the International System for Human Cytogenetic Nomenclature (ISCN) Juan Ramon Gonzalez Garcia, Juan Pablo Meza-Espinoza, Gita Vasers Massey, Howard J. Weinstein, and Alvin Zipursky Blood 2006 108: 3952-3953. [Full Text] [PDF]   PASD1 is a potential multiple myeloma–associated antigen Surinder S. Sahota, C. Madusha Goonewardena, Christopher D. O. Cooper, Amanda P. Liggins, Kamal Ait-Tahar, Niklas Zojer, Freda K. Stevenson, Alison H. Banham, and Karen Pulford Blood 2006 108: 3953-3955. [Full Text] [PDF]   To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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