|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 92 No. 10 (November 15), 1998:
pp. 3780-3792
Efficient and Rapid Induction of a Chronic Myelogenous
Leukemia-Like Myeloproliferative Disease in Mice Receiving P210
bcr/abl-Transduced Bone Marrow
Warren S. Pear,
Juli P. Miller,
Lanwei Xu,
John C. Pui,
Benny Soffer,
Robert C. Quackenbush,
Ann Marie Pendergast,
Roderick Bronson,
Jon C. Aster,
Martin L. Scott, and
David Baltimore
From the Department of Pathology and Institute for Medicine and
Engineering, University of Pennsylvania, Philadelphia, PA; the
Department of Internal Medicine (Hematology/Oncology), Pharmacology,
and Cancer Biology, Duke University School of Medicine, Durham, NC; the
Department of Veterinary Medicine, Tufts University, Boston, MA; the
Department of Pathology, Brigham and Women's Hospital, Boston, MA; and
the Department of Biology, Massachusetts Institute of Technology,
Cambridge, MA.
Expression of the 210-kD bcr/abl fusion oncoprotein can cause a
chronic myelogenous leukemia (CML)-like disease in mice receiving bone
marrow cells transduced by bcr/abl-encoding retroviruses. However,
previous methods failed to yield this disease at a frequency sufficient
enough to allow for its use in the study of CML pathogenesis. To
overcome this limitation, we have developed an efficient and reproducible method for inducing a CML-like disease in mice receiving P210 bcr/abl-transduced bone marrow cells. All mice receiving P210
bcr/abl-transduced bone marrow cells succumb to a myeloproliferative disease between 3 and 5 weeks after bone marrow transplantation. The
myeloproliferative disease recapitulates many of the hallmarks of human
CML and is characterized by high white blood cell counts and extensive
extramedullary hematopoiesis in the spleen, liver, bone marrow, and
lungs. Use of a retroviral vector coexpressing P210 bcr/abl and green
fluorescent protein shows that the vast majority of bcr/abl-expressing
cells are myeloid. Analysis of the proviral integration pattern shows
that, in some mice, the myeloproliferative disease is clonal. In
multiple mice, the CML-like disease has been transplantable, inducing a
similar myeloproliferative syndrome within 1 month of transfer to
sublethally irradiated syngeneic recipients. The disease in many of
these mice has progressed to the development of acute lymphoma/leukemia
resembling blast crisis. These results demonstrate that murine CML
recapitulates important features of human CML. As such, it should be an
excellent model for addressing specific issues relating to the
pathogenesis and treatment of this disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Antoku, K. Saksela, G. M. Rivera, and B. J. Mayer
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors
J. Cell Sci.,
September 15, 2008;
121(18):
3071 - 3082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ko, N. Patel, T. Ikawa, H. Kawamoto, O. Frank, R. R. Rivera, R. A. Van Etten, and C. Murre
Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease
PNAS,
September 2, 2008;
105(35):
12967 - 12972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Kim, T. Miwa, Y. Kimura, R. A. Schwendener, M. van Lookeren Campagne, and W.-C. Song
Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
Blood,
August 15, 2008;
112(4):
1109 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Li, H. Yao, Z. Zhang, M. Li, Y. Luo, P. R. Thompson, D. S. Gilmour, and Y. Wang
Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4
Mol. Cell. Biol.,
August 1, 2008;
28(15):
4745 - 4758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux
CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL
J. Immunol.,
July 15, 2008;
181(2):
1001 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mulky, T. V. Cohen, S. V. Kozlov, B. Korbei, R. Foisner, C. L. Stewart, and V. N. KewalRamani
The LEM Domain Proteins Emerin and LAP2{alpha} Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections
J. Virol.,
June 15, 2008;
82(12):
5860 - 5868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kavalerchik, D. Goff, and C. H.M. Jamieson
Chronic Myeloid Leukemia Stem Cells
J. Clin. Oncol.,
June 10, 2008;
26(17):
2911 - 2915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tabone-Eglinger, F. Subra, H. El Sayadi, L. Alberti, E. Tabone, J.-P. Michot, N. Theou-Anton, A. Lemoine, J.-Y. Blay, and J.-F. Emile
KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors
Clin. Cancer Res.,
April 15, 2008;
14(8):
2285 - 2294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Podsypanina, K. Politi, L. J. Beverly, and H. E. Varmus
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
PNAS,
April 1, 2008;
105(13):
5242 - 5247.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Matte-Martone, J. Liu, D. Jain, J. McNiff, and W. D. Shlomchik
CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL
Blood,
April 1, 2008;
111(7):
3884 - 3892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Zheng, C. Matte-Martone, H. Li, B. E. Anderson, S. Venketesan, H. Sheng Tan, D. Jain, J. McNiff, and W. D. Shlomchik
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
Blood,
February 15, 2008;
111(4):
2476 - 2484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Furmanski, C. Ferreira, I. Bartok, S. Dimakou, J. Rice, F. K. Stevenson, M. M. Millrain, E. Simpson, and J. Dyson
Public T Cell Receptor -Chains Are Not Advantaged during Positive Selection
J. Immunol.,
January 15, 2008;
180(2):
1029 - 1039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. John, J. L. Clements, L. M. Russell, and L. A. Garrett-Sinha
Ets-1 Regulates Plasma Cell Differentiation by Interfering with the Activity of the Transcription Factor Blimp-1
J. Biol. Chem.,
January 11, 2008;
283(2):
951 - 962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ren, Z. Chen, L. Chen, N. T. Woods, G. W. Reuther, J. Q. Cheng, H.-g. Wang, and J. Wu
Shp2E76K Mutant Confers Cytokine-independent Survival of TF-1 Myeloid Cells by Up-regulating Bcl-XL
J. Biol. Chem.,
December 14, 2007;
282(50):
36463 - 36473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Metcalf, S. Glaser, S. Mifsud, L. Di Rago, and L. Robb
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells
PNAS,
December 11, 2007;
104(50):
20013 - 20018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Michie, A. C. Chan, M. Ciofani, M. Carleton, J. M. Lefebvre, Y. He, D. M. Allman, D. L. Wiest, J. C. Zuniga-Pflucker, and D. J. Izon
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals
Int. Immunol.,
December 1, 2007;
19(12):
1421 - 1430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Dileepan, S. C. Kachlany, N. V. Balashova, J. Patel, and S. K. Maheswaran
Human CD18 Is the Functional Receptor for Aggregatibacter actinomycetemcomitans Leukotoxin
Infect. Immun.,
October 1, 2007;
75(10):
4851 - 4856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. O'Carroll, I. Mecklenbrauker, P. P. Das, A. Santana, U. Koenig, A. J. Enright, E. A. Miska, and A. Tarakhovsky
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
Genes & Dev.,
August 15, 2007;
21(16):
1999 - 2004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Caslini, Z. Yang, M. El-Osta, T. A. Milne, R. K. Slany, and J. L. Hess
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Cancer Res.,
August 1, 2007;
67(15):
7275 - 7283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chu, L. Li, H. Singh, and R. Bhatia
BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia
Cancer Res.,
July 15, 2007;
67(14):
7045 - 7053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Peng, J. Brain, Y. Hu, A. Goodrich, L. Kong, D. Grayzel, R. Pak, M. Read, and S. Li
Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
Blood,
July 15, 2007;
110(2):
678 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hosen, T. Yamane, M. Muijtjens, K. Pham, M. F. Clarke, and I. L. Weissman
Bmi-1-Green Fluorescent Protein-Knock-In Mice Reveal the Dynamic Regulation of Bmi-1 Expression in Normal and Leukemic Hematopoietic Cells
Stem Cells,
July 1, 2007;
25(7):
1635 - 1644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yan, J.-K. Luo, K. J. Ritchie, I. Sakai, K. Takeuchi, R. Ren, and D.-E. Zhang
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling
Blood,
July 1, 2007;
110(1):
305 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Grande-Garcia, A. Echarri, J. de Rooij, N. B. Alderson, C. M. Waterman-Storer, J. M. Valdivielso, and M. A. del Pozo
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases
J. Cell Biol.,
May 21, 2007;
177(4):
683 - 694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. DeKoter, B. L. Schweitzer, M. B. Kamath, D. Jones, H. Tagoh, C. Bonifer, D. A. Hildeman, and K. J. Huang
Regulation of the Interleukin-7 Receptor {alpha} Promoter by the Ets Transcription Factors PU.1 and GA-binding Protein in Developing B Cells
J. Biol. Chem.,
May 11, 2007;
282(19):
14194 - 14204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Courreges, D. Burzyn, I. Nepomnaschy, I. Piazzon, and S. R. Ross
Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection
J. Virol.,
April 15, 2007;
81(8):
3769 - 3777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Zou, H. Chen, A. A. Schmaier, R. O. Hynes, and M. L. Kahn
Structure-function analysis reveals discrete {beta}3 integrin inside-out and outside-in signaling pathways in platelets
Blood,
April 15, 2007;
109(8):
3284 - 3290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Roberts, J. P. H. Lauritsen, M. Cooney, R. E. Parrott, E. O. Sajaroff, C. M. Win, M. D. Keller, J. H. Carpenter, J. Carabana, M. S. Krangel, et al.
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3{zeta} subunit of the T-cell antigen receptor complex
Blood,
April 15, 2007;
109(8):
3198 - 3206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. O. Yang, A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
J. Biol. Chem.,
March 30, 2007;
282(13):
9358 - 9363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Corbett, C. A. Forbes, D. Moro, and A. A. Scalzo
Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes
J. Gen. Virol.,
March 1, 2007;
88(3):
758 - 769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Kantarjian, F. Giles, A. Quintas-Cardama, and J. Cortes
Important Therapeutic Targets in Chronic Myelogenous Leukemia
Clin. Cancer Res.,
February 15, 2007;
13(4):
1089 - 1097.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Taschner, C. Koesters, B. Platzer, A. Jorgl, W. Ellmeier, T. Benesch, and H. Strobl
Down-regulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors
Blood,
February 1, 2007;
109(3):
971 - 979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
PNAS,
January 23, 2007;
104(4):
1260 - 1265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Sherrill and W. E. Miller
G Protein-coupled Receptor (GPCR) Kinase 2 Regulates Agonist-independent Gq/11 Signaling from the Mouse Cytomegalovirus GPCR M33
J. Biol. Chem.,
December 29, 2006;
281(52):
39796 - 39805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Skaggs, M. E. Gorre, A. Ryvkin, M. R. Burgess, Y. Xie, Y. Han, E. Komisopoulou, L. M. Brown, J. A. Loo, E. M. Landaw, et al.
Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants
PNAS,
December 19, 2006;
103(51):
19466 - 19471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. G.P. Bumm, C. Elsea, A. S. Corbin, M. Loriaux, D. Sherbenou, L. Wood, J. Deininger, R. T. Silver, B. J. Druker, and M. W.N. Deininger
Characterization of Murine JAK2V617F-Positive Myeloproliferative Disease
Cancer Res.,
December 1, 2006;
66(23):
11156 - 11165.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ma, A. Turetsky, L. Trinh, and R. Lu
IFN Regulatory Factor 4 and 8 Promote Ig Light Chain {kappa} Locus Activation in Pre-B Cell Development
J. Immunol.,
December 1, 2006;
177(11):
7898 - 7904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hu, S. Swerdlow, T. M. Duffy, R. Weinmann, F. Y. Lee, and S. Li
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
PNAS,
November 7, 2006;
103(45):
16870 - 16875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Glaser, D. Metcalf, L. Wu, A. H. Hart, L. DiRago, S. Mifsud, A. D'Amico, S. Dagger, C. Campo, A. C. Chan, et al.
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia
PNAS,
October 31, 2006;
103(44):
16460 - 16465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Middleton, A. M. Zukas, T. Rubinstein, M. Jacob, P. Zhu, L. Zhao, I. Blair, and E. Pure
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
J. Exp. Med.,
October 30, 2006;
203(11):
2529 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Kim, T. Miwa, and W.-C. Song
Retrovirus-Mediated Over-Expression of Decay-Accelerating Factor Rescues Crry-Deficient Erythrocytes from Acute Alternative Pathway Complement Attack
J. Immunol.,
October 15, 2006;
177(8):
5558 - 5566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
