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Differentiation and proliferation of hematopoietic stem cells
M Ogawa
Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston,
SC 29401-5799.
Available evidence indicates that qualitative changes in hematopoietic stem
cells and progenitors, such as the decision of stem cells to self- renew or
differentiate, or selection of lineage potentials by the multipotential
progenitors during differentiation (commitment), are intrinsic properties
of the progenitors and are stochastic in nature. In-contrast, proliferative
kinetics of the progenitors, namely survival and expansion of the
progenitors, appear to be controlled by a number of interacting cytokines.
While proliferation and maturation of committed progenitors is controlled
by late-acting lineage-specific factors such as Ep, M-CSF, G-CSF, and IL-5,
progenitors at earlier stages of development are controlled by a group of
several overlapping cytokines. IL-3, GM-CSF, and IL-4 regulate
proliferation of multipotential progenitors only after they exit from G0
and begin active cell proliferation. Triggering of cycling by dormant
primitive progenitors and maintenance of B-cell potential of the primitive
progenitors appears to require interactions of early acting cytokines
including IL-6, G-CSF, IL-11, IL-12, LIF, and SF. Currently, this simple
model fits our understanding of the interactions of growth factors with
hematopoietic progenitors. Naturally the model risks oversimplification of
a very complex process. However, because the model is testable, it will
hopefully challenge investigators to design new experiments to examine its
validity.
Volume 81,
Issue 11,
pp. 2844-2853,
06/01/1993
Copyright © 1993 by The American Society of Hematology
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(2008)
sqb.2008.73.031v1.
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111(12):
5427 - 5432.
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June 1, 2008;
26(6):
1556 - 1564.
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|
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|
|
|
|
|
|
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February 15, 2008;
180(4):
2045 - 2053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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January 15, 2008;
111(2):
492 - 503.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
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October 15, 2007;
110(8):
2955 - 2964.
[Abstract]
[Full Text]
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|
|
|
|
|
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Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryocytic, and granulocytic lineage
J. Leukoc. Biol.,
October 1, 2007;
82(4):
986 - 1002.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Aoyama, C. Delaney, B. Varnum-Finney, A. D. Kohn, R. T. Moon, and I. D. Bernstein
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25(10):
2488 - 2497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Berthet, M. C. Rodriguez-Galan, D. L. Hodge, J. Gooya, V. Pascal, H. A. Young, J. Keller, R. Bosselut, and P. Kaldis
Hematopoiesis and Thymic Apoptosis Are Not Affected by the Loss of Cdk2
Mol. Cell. Biol.,
July 15, 2007;
27(14):
5079 - 5089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Bowie, D. G. Kent, M. R. Copley, and C. J. Eaves
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June 1, 2007;
109(11):
5043 - 5048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Araki, K. Yoshinaga, P. Boccuni, Y. Zhao, R. Hoffman, and N. Mahmud
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April 15, 2007;
109(8):
3570 - 3578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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56(4):
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|
|
|
|
|
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|
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|
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|
|
|
|
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|
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|
|
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|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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[Abstract]
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|
|
|
|
|
|
|
F. Hermitte, P. Brunet de la Grange, F. Belloc, V. Praloran, and Z. Ivanovic
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January 1, 2006;
24(1):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Kim, N. I. Kim, Y.-K. Oh, Y.-J. Kim, J. Youn, and M.-J. Ahn
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17(12):
1525 - 1531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Baksh, J. E. Davies, and P. W. Zandstra
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November 1, 2005;
106(9):
3012 - 3019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Kindler
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J. Leukoc. Biol.,
October 1, 2005;
78(4):
836 - 844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Hubin, C. Humblet, Z. Belaid, C. Lambert, J. Boniver, A. Thiry, and M.-P. Defresne
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October 1, 2005;
23(10):
1626 - 1633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Komor, S. Guller, C. D. Baldus, S. de Vos, D. Hoelzer, O. G. Ottmann, and W.-K. Hofmann
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September 1, 2005;
23(8):
1154 - 1169.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Mandle, H. Einsele, M. Schaller, D. Neumann, W. Vogel, I. B. Autenrieth, and V. A. J. Kempf
Infection of human CD34+ progenitor cells with Bartonella henselae results in intraerythrocytic presence of B henselae
Blood,
August 15, 2005;
106(4):
1215 - 1222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. van Grevenynghe, M. Bernard, S. Langouet, C. Le Berre, T. Fest, and O. Fardel
Human CD34-Positive Hematopoietic Stem Cells Constitute Targets for Carcinogenic Polycyclic Aromatic Hydrocarbons
J. Pharmacol. Exp. Ther.,
August 1, 2005;
314(2):
693 - 702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kamata, J. Kang, T.-H. Lee, L. Wojnowski, C. A. Pritchard, and A. D. Leavitt
A critical function for B-Raf at multiple stages of myelopoiesis
Blood,
August 1, 2005;
106(3):
833 - 840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ogata, C. Satoh, M. Tachibana, H. Hyodo, H. Tamura, K. Dan, T. Kimura, Y. Sonoda, and T. Tsuji
Identification and Hematopoietic Potential of CD45- Clonal Cells with Very Immature Phenotype (CD45-CD34-CD38-Lin-) in Patients with Myelodysplastic Syndromes
Stem Cells,
May 1, 2005;
23(5):
619 - 630.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. F. Srour, X. Tong, K. W. Sung, P. A. Plett, S. Rice, J. Daggy, C. T. Yiannoutsos, R. Abonour, and C. M. Orschell
Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34+CD38-/lo cells in G0
Blood,
April 15, 2005;
105(8):
3109 - 3116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Xu, E. Rosler, J. Jiang, J. S. Lebkowski, J. D. Gold, C. O'Sullivan, K. Delavan-Boorsma, M. Mok, A. Bronstein, and M. K. Carpenter
Basic Fibroblast Growth Factor Supports Undifferentiated Human Embryonic Stem Cell Growth Without Conditioned Medium
Stem Cells,
March 1, 2005;
23(3):
315 - 323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Terszowski, C. Waskow, P. Conradt, D. Lenze, J. Koenigsmann, D. Carstanjen, I. Horak, and H.-R. Rodewald
Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E)
Blood,
March 1, 2005;
105(5):
1937 - 1945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Roeder, L. M. Kamminga, K. Braesel, B. Dontje, G. de Haan, and M. Loeffler
Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization
Blood,
January 15, 2005;
105(2):
609 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Zhou, X. Kong, and D. I. H. Linzer
Enhanced Recovery from Thrombocytopenia and Neutropenia in Mice Constitutively Expressing a Placental Hematopoietic Cytokine
Endocrinology,
January 1, 2005;
146(1):
64 - 70.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Wheeler, P. J. Reddig, K. J. Ness, C. P. Leith, T. D. Oberley, and A. K. Verma
Overexpression of Protein Kinase C-{epsilon} in the Mouse Epidermis Leads to a Spontaneous Myeloproliferative-Like Disease
Am. J. Pathol.,
January 1, 2005;
166(1):
117 - 126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Hirschmann-Jax, A. E. Foster, G. G. Wulf, J. G. Nuchtern, T. W. Jax, U. Gobel, M. A. Goodell, and M. K. Brenner
A distinct "side population" of cells with high drug efflux capacity in human tumor cells
PNAS,
September 28, 2004;
101(39):
14228 - 14233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Martinovic, S. Mazic, V. Kisic, N. Basic, J. Jakic-Razumovic, F. Borovecki, D. Batinic, P. Simic, L. Grgurevic, B. Labar, et al.
Expression of Bone Morphogenetic Proteins in Stromal Cells from Human Bone Marrow Long-term Culture
J. Histochem. Cytochem.,
September 1, 2004;
52(9):
1159 - 1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Araki, N. Katayama, Y. Yamashita, H. Mano, A. Fujieda, E. Usui, H. Mitani, K. Ohishi, K. Nishii, M. Masuya, et al.
Reprogramming of human postmitotic neutrophils into macrophages by growth factors
Blood,
April 15, 2004;
103(8):
2973 - 2980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
