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NB4, a maturation inducible cell line with t(15;17) marker isolated from a
human acute promyelocytic leukemia (M3)
M Lanotte, V Martin-Thouvenin, S Najman, P Balerini, F Valensi and R Berger
INSERM U-301, SDI No 15954.1 CNRS, Centre Hayem, Paris, France.
Acute promyelocytic leukemia (APL) is a well-defined entity among acute
leukemia, cytogenetically characterized by a t(15;17) (q22;q11-12)
translocation. In vitro and in vivo studies suggest that all-trans retinoic
acid (RA) treatment restores cell maturation. We have isolated the first
permanent cell line with t(15;17), derived from the marrow of a patient
with APL in relapse. The establishment of the cell line, its morphologic,
karyotypic, and immunohistochemical features are reported. RA induced cell
line maturation. Cells strongly expressed myeloid markers, but also some
T-cell markers. Additional karyotypic abnormalities, a 12p rearrangement
and the possible presence of a homogeneous staining region (HSR) on 19q+
are discussed both in relation to T-cell (CD2, CD4) and monocyte (CD9)
markers, and to the acquired cell growth autonomy. The cell line represents
a remarkable tool for biomolecular studies.
Volume 77,
Issue 5,
pp. 1080-1086,
03/01/1991
Copyright © 1991 by The American Society of Hematology
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