|
|
 Previous Article | Table of Contents | Next Article 
Induction of phagocytosis by a protein tyrosine kinase
ZK Indik, JG Park, XQ Pan and AD Schreiber
Department of Medicine, University of Pennsylvania School of Medicine,
Philadelphia.
The transmission of extracellular signals to cellular targets by many
noncatalytic surface receptors is dependent on interaction between
cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing
sequences in the cytoplasmic domain of the receptor or an associated
subunit. Isoforms of each of the three classes of the noncatalytic Fc gamma
receptors, Fc gamma RI, Fc gamma RII, and Fc gamma RIII, are able to
transmit a phagocytic signal in transfected COS-1 cells. Both Fc gamma RI
and Fc gamma RIIIA require the gamma subunit for this signaling event. The
protein tyrosine kinase Syk dramatically enhances phagocytosis mediated by
both these receptors and increases the number of cells able to mediate
phagocytosis. Two gamma chain cytoplasmic YXXL sequences are required for
this effect. The action of Syk is less pronounced on the phagocytic Fc
gamma RII receptor, Fc gamma RIIA, which does not require the gamma chain
for phagocytosis. However, Syk allows phagocytosis by the nonphagocytic Fc
gamma RII receptor Fc gamma RIIB2, which contains only a single YXXL
sequence, when an additional tyrosine-containing sequence, YMTL, is
introduced. These studies indicate that the efficiency of phagocytosis is
markedly enhanced by the presence of a specific protein tyrosine kinase.
Volume 85,
Issue 5,
pp. 1175-1180,
03/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y.-W. Huang, M. Yan, R. F. Collins, J. E. DiCiccio, S. Grinstein, and W. S. Trimble
Mammalian Septins Are Required for Phagosome Formation
Mol. Biol. Cell,
April 1, 2008;
19(4):
1717 - 1726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Polumuri, V. Y. Toshchakov, and S. N. Vogel
Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fc{gamma} Receptor Ligation in Murine Macrophages
J. Immunol.,
July 1, 2007;
179(1):
236 - 246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes
J. Immunol.,
March 1, 2007;
178(5):
2862 - 2871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Leeansyah, B. D. Wines, S. M. Crowe, and A. Jaworowski
The Mechanism Underlying Defective Fc{gamma} Receptor-Mediated Phagocytosis by HIV-1-Infected Human Monocyte-Derived Macrophages
J. Immunol.,
January 15, 2007;
178(2):
1096 - 1104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-Y. Huang, D. R. Barreda, R. G. Worth, Z. K. Indik, M.-K. Kim, P. Chien, and A. D. Schreiber
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
J. Leukoc. Biol.,
December 1, 2006;
80(6):
1553 - 1562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ulanova, L. Puttagunta, M. Marcet-Palacios, M. Duszyk, U. Steinhoff, F. Duta, M.-K. Kim, Z. K. Indik, A. D. Schreiber, and A. D. Befus
Syk tyrosine kinase participates in {beta}1-integrin signaling and inflammatory responses in airway epithelial cells
Am J Physiol Lung Cell Mol Physiol,
March 1, 2005;
288(3):
L497 - L507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Herre, A. S. J. Marshall, E. Caron, A. D. Edwards, D. L. Williams, E. Schweighoffer, V. Tybulewicz, C. R. e Sousa, S. Gordon, and G. D. Brown
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
Blood,
December 15, 2004;
104(13):
4038 - 4045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Moroni, V. Soldatenkov, L. Zhang, Y. Zhang, G. Stoica, E. Gehan, B. Rashidi, B. Singh, M. Ozdemirli, and S. C. Mueller
Progressive Loss of Syk and Abnormal Proliferation in Breast Cancer Cells
Cancer Res.,
October 15, 2004;
64(20):
7346 - 7354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-Y. Huang, S. Hunter, M.-K. Kim, P. Chien, R. G. Worth, Z. K. Indik, and A. D. Schreiber
The monocyte Fc{gamma} receptors Fc{gamma}RI/{gamma} and Fc{gamma}RIIA differ in their interaction with Syk and with Src-related tyrosine kinases
J. Leukoc. Biol.,
August 1, 2004;
76(2):
491 - 499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Albelda, K. C. Lau, P. Chien, Z.-Y. Huang, E. Arguiris, A. Bohen, J. Sun, J. A. Billet, M. Christofidou-Solomidou, Z. K. Indik, et al.
Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fc{gamma} Receptor Function
Am. J. Respir. Cell Mol. Biol.,
August 1, 2004;
31(2):
246 - 255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. F. Rosse, P. Hillmen, and A. D. Schreiber
Immune-Mediated Hemolytic Anemia
Hematology,
January 1, 2004;
2004(1):
48 - 62.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-K. Kim, Z.-Y. Huang, P.-H. Hwang, B. A. Jones, N. Sato, S. Hunter, T.-H. Kim-Han, R. G. Worth, Z. K. Indik, and A. D. Schreiber
Fc{gamma} receptor transmembrane domains: role in cell surface expression, {gamma} chain interaction, and phagocytosis
Blood,
June 1, 2003;
101(11):
4479 - 4484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Santini, B. Scappini, Z. K. Indik, A. Gozzini, P. Rossi Ferrini, and A. D. Schreiber
The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal
Blood,
June 1, 2003;
101(11):
4615 - 4622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. Mahabeleshwar and G. C. Kundu
Syk, a Protein-tyrosine Kinase, Suppresses the Cell Motility and Nuclear Factor kappa B-mediated Secretion of Urokinase Type Plasminogen Activator by Inhibiting the Phosphatidylinositol 3'-Kinase Activity in Breast Cancer Cells
J. Biol. Chem.,
February 14, 2003;
278(8):
6209 - 6221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Hinkovska-Galcheva, L. Boxer, P. J. Mansfield, A. D. Schreiber, and J. A. Shayman
Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis
J. Biol. Chem.,
January 3, 2003;
278(2):
974 - 982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Strzelecka-Kiliszek, K. Kwiatkowska, and A. Sobota
Lyn and Syk Kinases Are Sequentially Engaged in Phagocytosis Mediated by Fc{gamma}R
J. Immunol.,
December 15, 2002;
169(12):
6787 - 6794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Garcia-Garcia and C. Rosales
Signal transduction during Fc receptor-mediated phagocytosis
J. Leukoc. Biol.,
December 1, 2002;
72(6):
1092 - 1108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC
Blood,
August 13, 2002;
100(5):
1852 - 1859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Stenton, M. Ulanova, R. E. Dery, S. Merani, M.-K. Kim, M. Gilchrist, L. Puttagunta, S. Musat-Marcu, D. James, A. D. Schreiber, et al.
Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase
J. Immunol.,
July 15, 2002;
169(2):
1028 - 1036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kedzierska, P. Ellery, J. Mak, S. R. Lewin, S. M. Crowe, and A. Jaworowski
HIV-1 Down-Modulates {gamma} Signaling Chain of Fc{gamma}R in Human Macrophages: A Possible Mechanism for Inhibition of Phagocytosis
J. Immunol.,
March 15, 2002;
168(6):
2895 - 2903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Kim, X. Peng, P. K. De, R. L. Geahlen, and D. L. Durden
PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac
Blood,
January 15, 2002;
99(2):
694 - 697.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Majeed, E. Caveggion, C. A. Lowell, and G. Berton
Role of Src kinases and Syk in Fc{gamma} receptor-mediated phagocytosis and phagosome-lysosome fusion
J. Leukoc. Biol.,
November 1, 2001;
70(5):
801 - 811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kedzierska, N. J. Vardaxis, A. Jaworowski, and S. M. Crowe
Fc{gamma}R-mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF
J. Leukoc. Biol.,
August 1, 2001;
70(2):
322 - 328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. May and L. Machesky
Phagocytosis and the actin cytoskeleton
J. Cell Sci.,
January 3, 2001;
114(6):
1061 - 1077.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. R. Stenton, M.-K. Kim, O. Nohara, C.-F. Chen, N. Hirji, F. L. Wills, M. Gilchrist, P.-H. Hwang, J.-G. Park, W. Finlay, et al.
Aerosolized Syk Antisense Suppresses Syk Expression, Mediator Release from Macrophages, and Pulmonary Inflammation
J. Immunol.,
April 1, 2000;
164(7):
3790 - 3797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Fitzer-Attas, M. Lowry, M. T. Crowley, A. J. Finn, F. Meng, A. L. DeFranco, and C. A. Lowell
Fc{gamma} Receptor-mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn
J. Exp. Med.,
February 21, 2000;
191(4):
669 - 682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. B. Raeder, P. J. Mansfield, V. Hinkovska-Galcheva, J. A. Shayman, and L. A. Boxer
Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis
J. Immunol.,
December 15, 1999;
163(12):
6785 - 6793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sato, M.-K. Kim, and A. D. Schreiber
Enhancement of Fc{gamma} Receptor-Mediated Phagocytosis by Transforming Mutants of Cbl
J. Immunol.,
December 1, 1999;
163(11):
6123 - 6131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Edberg, A. M. F. Yee, D. S. Rakshit, D. J. Chang, J. A. Gokhale, Z. K. Indik, A. D. Schreiber, and R. P. Kimberly
The Cytoplasmic Domain of Human Fcgamma RIa Alters the Functional Properties of the Fcgamma RI{middle dot}gamma -Chain Receptor Complex
J. Biol. Chem.,
October 15, 1999;
274(42):
30328 - 30333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. P. Downey, R. J. Botelho, J. R. Butler, Y. Moltyaner, P. Chien, A. D. Schreiber, and S. Grinstein
Phagosomal Maturation, Acidification, and Inhibition of Bacterial Growth in Nonphagocytic Cells Transfected with Fcgamma RIIA Receptors
J. Biol. Chem.,
October 1, 1999;
274(40):
28436 - 28444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pricop, J. Gokhale, P. Redecha, S. C. Ng, and J. E. Salmon
Reactive Oxygen Intermediates Enhance Fc{gamma} Receptor Signaling and Amplify Phagocytic Capacity
J. Immunol.,
June 15, 1999;
162(12):
7041 - 7048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Kusner, C. F. Hall, and S. Jackson
Fc{gamma} Receptor-Mediated Activation of Phospholipase D Regulates Macrophage Phagocytosis of IgG-Opsonized Particles
J. Immunol.,
February 15, 1999;
162(4):
2266 - 2274.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Kiefer, J. Brumell, N. Al-Alawi, S. Latour, A. Cheng, A. Veillette, S. Grinstein, and T. Pawson
The Syk Protein Tyrosine Kinase Is Essential for Fcgamma Receptor Signaling in Macrophages and Neutrophils
Mol. Cell. Biol.,
July 1, 1998;
18(7):
4209 - 4220.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Hunter, Z. K. Indik, M.-K. Kim, M. D. Cauley, J.-G. Park, and A. D. Schreiber
Inhibition of Fcgamma Receptor-Mediated Phagocytosis by a Nonphagocytic Fcgamma Receptor
Blood,
March 1, 1998;
91(5):
1762 - 1768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Barabé, C. Gilbert, N. Liao, S. G. Bourgoin, and P. H. Naccache
Crystal-induced neutrophil activation VI. Involvement of Fc{gamma}RIIIB (CD16) and CD11b in response to inflammatory microcrystals
FASEB J,
February 1, 1998;
12(2):
209 - 220.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. R. McDonald, K. R. Brunden, and G. E. Landreth
Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia
J. Neurosci.,
April 1, 1997;
17(7):
2284 - 2294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Olakanmi, J. B. Stokes, S. Pathan, and B. E. Britigan
Polyvalent Cationic Metals Induce the Rate of Transferrin-independent Iron Acquisition by HL-60 Cells
J. Biol. Chem.,
January 31, 1997;
272(5):
2599 - 2606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Cox, P. Chang, T. Kurosaki, and S. Greenberg
Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly
J. Biol. Chem.,
July 12, 1996;
271(28):
16597 - 16602.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Torres and R. D. Ye
Activation of the Mitogen-activated Protein Kinase Pathway by fMet-Leu-Phe in the Absence of Lyn and Tyrosine Phosphorylation of SHC in Transfected Cells
J. Biol. Chem.,
May 31, 1996;
271(22):
13244 - 13249.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Crowley, S. L. Harmer, and A. L. DeFranco
Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages
J. Biol. Chem.,
January 12, 1996;
271(2):
1145 - 1152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. C. Morton, I. E. van den Herik-Oudijk, P. Vossebeld, A. Snijders, A. J. Verhoeven, P. J. A. Capel, and J. G. J. van de Winkel
Functional Association between the Human Myeloid Immunoglobulin A Fc Receptor (CD89) and FcR [IMAGE] Chain
J. Biol. Chem.,
December 15, 1995;
270(50):
29781 - 29787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
