|
|
 Previous Article | Table of Contents | Next Article 
Neurologic complications after allogeneic marrow transplantation for sickle
cell anemia [see comments]
MC Walters, KM Sullivan, F Bernaudin, G Souillet, JP Vannier, FL Johnson, C Lenarsky, D Powars, N Bunin and K Ohene-Frempong
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Seven of 21 patients with sickle cell anemia developed neurologic
complications 5 to 243 days (median, 33 days) after allogeneic marrow
transplantation. Among these 7 patients, indications for transplantation
included either a past history of stroke (4 patients) or recurrent severe
vaso-occlusive events (3 patients). All received marrow from an
HLA-identical sibling after preparation with busulfan and cyclophosphamide,
and in 4 patients with antithymocyte globulin. Five of 6 patients
developing seizures received anticonvulsant and supportive treatment with
resolution of neurologic abnormalities. Three patients experienced
intracranial bleeding, which was fatal in two. Of the 14 patients free of
neurologic complications, 4 patients had experienced stroke before
transplantation. However, among all patients with prior stroke, the
incidence of intracranial hemorrhage was 38% (3/8), whereas none of the 13
patients without prior stroke developed posttransplant intracranial
bleeding (P = .026). We conclude that patients with sickle cell anemia are
at increased risk for neurologic complications after marrow ablative
therapy and that patients with prior stroke are at increased risk for
intracranial hemorrhage. Transplantation of patients before the onset of
overt stroke may reduce this risk.
Volume 85,
Issue 4,
pp. 879-884,
02/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. Bernaudin, G. Socie, M. Kuentz, S. Chevret, M. Duval, Y. Bertrand, J.-P. Vannier, K. Yakouben, I. Thuret, P. Bordigoni, et al.
Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease
Blood,
October 1, 2007;
110(7):
2749 - 2756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Strouse, M. L. Hulbert, M. R. DeBaun, L. C. Jordan, and J. F. Casella
Primary Hemorrhagic Stroke in Children With Sickle Cell Disease Is Associated With Recent Transfusion and Use of Corticosteroids
Pediatrics,
November 1, 2006;
118(5):
1916 - 1924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Goldstein, R. Adams, M. J. Alberts, L. J. Appel, L. M. Brass, C. D. Bushnell, A. Culebras, T. J. DeGraba, P. B. Gorelick, J. R. Guyton, et al.
Primary Prevention of Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline.
Circulation,
June 20, 2006;
113(24):
e873 - e923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Goldstein, R. Adams, M. J. Alberts, L. J. Appel, L. M. Brass, C. D. Bushnell, A. Culebras, T. J. DeGraba, P. B. Gorelick, J. R. Guyton, et al.
Primary Prevention of Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline.
Stroke,
June 1, 2006;
37(6):
1583 - 1633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. M. Coplin, M. S. Cochran, S. R. Levine, and S. W. Crawford
Stroke after bone marrow transplantation: Frequency, aetiology and outcome
Brain,
May 1, 2001;
124(5):
1043 - 1051.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al.
Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association
Circulation,
January 2, 2001;
103(1):
163 - 182.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al.
Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association
Stroke,
January 1, 2001;
32(1):
280 - 299.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Adams, K. Ohene-Frempong, and W. Wang
Sickle Cell and the Brain
Hematology,
January 1, 2001;
2001(1):
31 - 46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Adams
Lessons From the Stroke Prevention Trial in Sickle Cell Anemia (STOP) Study
J Child Neurol,
May 1, 2000;
15(5):
344 - 349.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. C. Walters, R. Storb, M. Patience, W. Leisenring, T. Taylor, J. E. Sanders, G. E. Buchanan, Z. R. Rogers, P. Dinndorf, S. C. Davies, et al.
Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report
Blood,
March 15, 2000;
95(6):
1918 - 1924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Sullivan, R. Parkman, and M. C. Walters
Bone Marrow Transplantation for Non-Malignant Disease
Hematology,
January 1, 2000;
2000(1):
319 - 338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Steinberg
Management of Sickle Cell Disease
N. Engl. J. Med.,
April 1, 1999;
340(13):
1021 - 1030.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Powars, P. S. Conti, W.-Y. Wong, P. Groncy, C. Hyman, E. Smith, N. Ewing, R. N. Keenan, C.-S. Zee, Y. Harold, et al.
Cerebral Vasculopathy in Sickle Cell Anemia: Diagnostic Contribution of Positron Emission Tomography
Blood,
January 1, 1999;
93(1):
71 - 79.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Screaton, L. Z. Penn, and C. P. Stanners
Carcinoembryonic Antigen, a Human Tumor Marker, Cooperates with Myc and Bcl-2 in Cellular Transformation
J. Cell Biol.,
May 19, 1997;
137(4):
939 - 952.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P. Vichinsky, L. A. Styles, L. H. Colangelo, E. C. Wright, O. Castro, B. Nickerson, and the Cooperative Study of Sickle Cell Disease
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Course
Blood,
March 1, 1997;
89(5):
1787 - 1792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Walters, M. Patience, W. Leisenring, J. R. Eckman, J. P. Scott, W. C. Mentzer, S. C. Davies, K. Ohene-Frempong, F. Bernaudin, D. C. Matthews, et al.
Bone Marrow Transplantation for Sickle Cell Disease
N. Engl. J. Med.,
August 8, 1996;
335(6):
369 - 376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. N. Schechter and G. P. Rodgers
Sickle Cell Anemia -- Basic Research Reaches the Clinic
N. Engl. J. Med.,
May 18, 1995;
332(20):
1372 - 1374.
[Full Text]
|
|
|
|
|
