|
|
 Previous Article | Table of Contents | Next Article 
Differential CD26-mediated activation of the CD3 and CD2 pathways after
CD6-depleted allogeneic bone marrow transplantation
J Kameoka, T Sato, Y Torimoto, K Sugita, RJ Soiffer, SF Schlossman, J Ritz and C Morimoto
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA
02115.
Patients who have undergone allogeneic bone marrow transplantation
(allo-BMT) are susceptible to a variety of opportunistic infectious
complications in the months to years after engraftment. Impaired in vitro
T-cell functions have been documented in these patients, and these T-cell
dysfunctions contribute to the prolonged immune deficiency after allo-BMT.
In the present study, we examined the expression of CD26 as well as the
reconstitution of CD26-mediated T-cell costimulation via the CD3 and CD2
pathways at various times in patients aged greater than 18 years after
CD6-positive, T-cell depleted allo- BMT. We found that the percentage of
CD26- and CD3-positive cells, as well as the levels of expression of both
antigens, was lower than in normal controls during the first 4 months after
CD6-depleted allo-BMT. Subsequently, the amount of lymphocytes expressing
CD3 and CD26 and the quantitative surface expression of CD3 and CD26 were
not significantly different in patients and normal controls. Functional
studies showed that CD26-mediated T-cell proliferation via the CD3 pathway
was considerably improved and almost reached normal levels by 1 year,
whereas recovery of CD26-mediated T-cell proliferation via the CD2 pathway
was delayed for at least 2 years after CD6-depleted allo-BMT. As CD26
involvement in the regulation of human thymocyte activation is restricted
preferentially to the CD3 pathway--unlike its involvement with both CD3 and
CD2 pathways of peripheral T cells--our results suggest that the different
effects of CD26-mediated costimulation via the CD3 and CD2 pathways after
CD6-depleted allo-BMT may be a reflection of peripheral T-cell immaturity
in those individuals, similar to that seen in mature medullary thymocytes
or cord T lymphocytes.
Volume 85,
Issue 4,
pp. 1132-1137,
02/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P. Ruiz, N. Zacharievich, and M. Shenkin
Clin. Vaccine Immunol.,
May 1, 1998;
5(3):
362 - 368.
[Abstract]
|
|
|
|
|
|
|
T. Sato, Y. Ohashi, K. Tachibana, R. J. Soiffer, J. Ritz, and C. Morimoto
Altered Tyrosine Phosphorylation Via the Very Late Antigen (VLA)/beta 1 Integrin Stimulation Is Associated With Impaired T-Cell Signaling Through VLA-4 After Allogeneic Bone Marrow Transplantation
Blood,
November 15, 1997;
90(10):
4222 - 4229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Soiffer, D. Fairclough, M. Robertson, E. Alyea, K. Anderson, A. Freedman, L. Bartlett-Pandite, D. Fisher, R. L. Schlossman, R. Stone, et al.
CD6-Depleted Allogeneic Bone Marrow Transplantation for Acute Leukemia in First Complete Remission
Blood,
April 15, 1997;
89(8):
3039 - 3047.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
