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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Djeha, A Articles by Brock, J. Search for Related Content PubMed PubMed Citation Articles by Djeha, A Articles by Brock, J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes A Djeha, JL Perez-Arellano, SL Hayes, R Oria, RJ Simpson, KB Raja and JH Brock Department of Immunology, University of Glasgow, Scotland, UK. Transferrin (Tf) plays an important role during immunologic activation by donating iron to activated lymphocytes. Therefore, synthesis by lymphomyeloid cells has been investigated. Mouse macrophages and macrophage cell lines synthesized Tf, with levels being markedly increased by gamma-interferon (gamma-IFN) and, to a lesser extent, by interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha (TNF alpha). Tf was also produced by phytohemagglutinin-stimulated human T cells and two T-cell lines and was increased by IL-2. Even after appropriate activation, none was synthesized by human macrophages or monocytic cell lines or by mouse T cells, T-cell lines, or thymus cells. In both species, B-lineage cell lines were negative. Tf was also synthesised by macrophages from congenitally hypotransferrinemic mice and was responsive to gamma-IFN, but levels were lower than those from normal controls. Synthesis by human and murine hepatoma cells was increased by IL-6 but unaffected by IL-1, TNF alpha, or gamma-IFN. Iron decreased synthesis by hepatoma cells but had no effect on the lymphomyeloid cells. Tf mRNA levels paralleled protein synthesis, suggesting that regulation was pre-translational. Thus, Tf synthesis by lymphomyeloid cells is regulated differently from hepatic synthesis, which is consistent with the suggestion that Tf may act in a paracrine (mouse) or autocrine (human) manner on activated lymphocytes. Volume 85, Issue 4, pp. 1036-1042, 02/15/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Mateos, J. H Brock, and J. L. Pérez-Arellano Iron metabolism in the lower respiratory tract Thorax, July 1, 1998; 53(7): 594 - 600. [Full Text]

	Copyright © 1995 by American Society of Hematology         Online ISSN: 1528-0020