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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sintnicolaas, K Articles by Brand, A Search for Related Content PubMed PubMed Citation Articles by Sintnicolaas, K Articles by Brand, A Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Leukocyte depletion of random single-donor platelet transfusions does not prevent secondary human leukocyte antigen-alloimmunization and refractoriness: a randomized prospective study K Sintnicolaas, M van Marwijk Kooij, HC van Prooijen, BA van Dijk, WL van Putten, FH Claas, VM Novotny and A Brand Department of Statistics, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. We studied the value of leukocyte depletion of platelet transfusions for the prevention of secondary human leukocyte antigen (HLA)- alloimmunization in patients with a high-risk of prior immunization induced by pregnancies. Seventy-five female patients with hematologic malignancies (mostly acute leukemia) and a history of pregnancy were randomized to receive either standard random single-donor platelet transfusions (mean leukocytes, 430 x 10(6) per transfusion) or leukocyte-depleted random single-donor platelet transfusions. Leukocyte depletion to less than 5 x 10(6) leukocytes per platelet transfusion (mean leukocytes, 2 x 10(6) per transfusion) was achieved by filtration. Of the 62 evaluable patients, refractoriness to random donor platelets occurred in 41% (14 of 34) of the patients in the standard group and in 29% (8 of 28) of the patients in the filtered group (P = .52); anti-HLA antibodies developed in 43% (9 of 21) of individuals in the standard group and 44% (11 of 25) of cases in the filtered group. The time toward refractoriness and development of anti- HLA antibodies was similar for both groups. We conclude that leukocyte depletion of random single-donor platelet products to less than 5 x 10(6) per transfusion does not reduce the incidence of refractoriness to random donor platelet transfusion because of boostering of anti-HLA antibodies. Volume 85, Issue 3, pp. 824-828, 02/01/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. D. Seftel, G. H. Growe, T. Petraszko, W. B. Benny, A. Le, C.-Y. Lee, J. J. Spinelli, H. J. Sutherland, P. Tsang, and D. E. Hogge Universal prestorage leukoreduction in Canada decreases platelet alloimmunization and refractoriness Blood, January 1, 2004; 103(1): 333 - 339. [Abstract] [Full Text] [PDF] C. A. Schiffer, K. C. Anderson, C. L. Bennett, S. Bernstein, L. S. Elting, M. Goldsmith, M. Goldstein, H. Hume, J. J. McCullough, R. E. McIntyre, et al. Platelet Transfusion for Patients With Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology J. Clin. Oncol., March 1, 2001; 19(5): 1519 - 1538. [Abstract] [Full Text] [PDF] The Trial to Reduce Alloimmunization to Platelets Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions N. Engl. J. Med., December 25, 1997; 337(26): 1861 - 1870. [Abstract] [Full Text] [PDF] M. S. Kruskall The Perils of Platelet Transfusions N. Engl. J. Med., December 25, 1997; 337(26): 1914 - 1915. [Full Text]

	Copyright © 1995 by American Society of Hematology         Online ISSN: 1528-0020