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Biosynthesis of granule proteins in normal human bone marrow cells.
Gelatinase is a marker of terminal neutrophil differentiation
N Borregaard, M Sehested, BS Nielsen, H Sengelov and L Kjeldsen
Department of Hematology, University Hospital, Rigshospitalet, Copenhagen,
Denmark.
Differentiation and maturation of myeloid cells is characterized by the
sequential acquisition of two distinct cytoplasmic granule subsets,
azurophil granules and specific granules. We recently showed the existence
of a third granule subset, gelatinase granules. To investigate whether
appearance of gelatinase granules marks a further step in maturation of
myeloid cells beyond the appearance of specific granules, we sorted normal
human bone marrow cells into one of three groups according to maturity by
centrifugation on Percoll density gradients. The biosynthesis of
myeloperoxidase (MPO) (an azurophil granule marker), lactoferrin and
neutrophil gelatinase-associated lipocalin NGAL (specific granules markers)
and gelatinase was then studied in each of these groups. We found that
gelatinase was synthesized mainly in the group containing band cells and
segmented cells. This contrasted with lactoferrin and NGAL, which were
synthesized almost exclusively in the group containing myelocytes and
metamyelocytes, and with MPO, which was mainly synthesized in the group
containing myeloblasts and promyelocytes. Immunocytochemistry was in full
agreement with the biosynthesis data, and showed that gelatinase appears in
band cells, whereas NGAL and lactoferrin both appear in myelocytes. Thus,
acquisition of gelatinase granules marks a step in neutrophil
differentiation beyond the appearance of specific granules.
Volume 85,
Issue 3,
pp. 812-817,
02/01/1995
Copyright © 1995 by The American Society of Hematology
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