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Expression of TAL-1 proteins in human tissues
K Pulford, N Lecointe, K Leroy-Viard, M Jones, D Mathieu-Mahul and DY Mason
University Department of Cellular Science, John Radcliffe Hospital, Oxford,
UK.
Rearrangement of the tal-1 gene (also known as SCL or TCL-5) occurs in at
least 25% of T-cell acute lymphoblastic leukemias (T-ALLs) and results in
the aberrant expression of tal-1 mRNA in the neoplastic cells. Also, tal-1
mRNA is constitutively expressed in erythroid precursors and
megakaryocytes. This report describes a direct immunocytochemical study of
the distribution and localization of TAL-1 protein in normal human tissues
and cell lines using four monoclonal antibodies raised against recombinant
TAL-1 proteins. One of these reagents recognizes a protein of 41 kD
molecular weight in in vitro- translated TAL-1 proteins, two others
recognize proteins of 39 and 41 kD molecular weight, and the fourth
antibody also recognizes a TAL-1 protein of 22 kD in addition to the 39-
and 41-kD proteins. These anti- TAL-1 antibodies label the nuclei of
erythroid precursor cells and megakaryocytes in fetal liver and adult bone
marrow. The punctate pattern of nuclear labeling suggests that TAL-1 may
comprise part of a novel nuclear structure, similar to that recently found
for the PML protein. The nuclei of T cell lines known to express mRNA
encoding the full-length TAL-1 protein (eg, CCRF-CEM, RPMI 8402, and
Jurkat) are also labeled. A study of normal human tissues (including
thymus) showed labeling of smooth muscle, some tissue macrophages, and
endothelial cells. TAL-1 protein is undetectable in other cell types. These
reagents may play an important role in the diagnosis of T-ALL and could
also be used in the context of lymphoma diagnosis on routinely fixed
material.
Volume 85,
Issue 3,
pp. 675-684,
02/01/1995
Copyright © 1995 by The American Society of Hematology
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