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A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically
expressed in leukemic and immature hematopoietic cells
W Tse, W Zhu, HS Chen and A Cohen
Division of Immunology/Cancer Research and Medical Genetics, Hospital for
Sick Children, Toronto, Ontario, Canada.
Translocations involving chromosomal band 11q23 are associated with
leukemias. These translocations fuse the MLL, a gene with sequence homology
to the Drosophila trithorax, to genes from a number of other chromosomal
loci. We have characterized two t(1;11)(q21;q23) translocations that fuse
the MLL gene to a novel gene, AF1q on chromosomal band 1q21, in two infants
with acute myelomonocytic leukemia (AMMOL). In one of these patients,
der(11) represents an inframe fusion of the N-terminal portion of MLL gene
to the complete AF1q open reading frame, whereas der(1) does not give rise
to an open reading frame. This observation suggests that the N-terminal
portion of MLL gene is critical for leukemogenesis in translocations
involving band 11q23. The predicted wild-type AF-1q product is a 9-kD
protein with no similarity to any other protein in the data banks. The AF1q
mRNA is highly expressed in the thymus but not in peripheral lymphoid
tissues. In contrast to its restricted distribution in normal hematopoietic
tissue, AF1q was expressed in all leukemic cell lines tested.
Volume 85,
Issue 3,
pp. 650-656,
02/01/1995
Copyright © 1995 by The American Society of Hematology
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