|
|
 Previous Article | Table of Contents | Next Article 
Membrane-bound Steel factor induces more persistent tyrosine kinase
activation and longer life span of c-kit gene-encoded protein than its
soluble form
K Miyazawa, DA Williams, A Gotoh, J Nishimaki, HE Broxmeyer and K Toyama
First Department of Internal Medicine (Hematology and Oncology), Tokyo
Medical College, Japan.
Alternative splicing of exon 6 results in the production of two isoforms of
Steel factor (SLF): the membrane-bound and soluble forms. To investigate
differences in the kinetics of c-kit tyrosine kinase activated by these two
isoforms, we used a stromal cell line (SI/SI4) established from SI/SI
homozygous murine embryo fetal liver and its stable transfectants
containing either hSCF248 cDNA (including exon 6; secreted form) or hSCF220
cDNA (lacking exon 6; membrane-bound form) as the source of each isoform.
Interaction of factor dependent myeloid cell line MO7e with stromal cells
producing either isoform resulted in activated c-kit tyrosine kinase and
induction of the same series of tyrosine phosphorylated cellular proteins
in MO7e cells. However, SI4- h220 (membrane-bound form) induced more
persistent activation of c-kit kinase than SI4-h248 (soluble form) did.
Flow cytometric analysis and pulse-chase studies using [35S]methionine
showed that SI4-h248 induced rapid downmodulation of cell-surface c-kit
expression and its protein degradation in MO7e cells, whereas SI4-h220
induced more prolonged life span of c-kit protein. Addition of soluble
recombinant human SLF to SI4- h220 cultures enhanced reduction of
cell-surface c-kit expression and its protein degradation. Because the
kinetics of c-kit inactivation strikingly fits with the protein degradation
rates of c-kit under the conditions described above, rapid proteolysis of
c-kit protein induced by soluble SLF stimulation may function as a
"turn-off switch" for activated c-kit kinase.
Volume 85,
Issue 3,
pp. 641-649,
02/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. Kenins, J. W. Gill, R. L. Boyd, G. A. Hollander, and A. Wodnar-Filipowicz
Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation
J. Exp. Med.,
March 17, 2008;
205(3):
523 - 531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Klinck, A. Bramard, L. Inkel, G. Dufresne-Martin, J. Gervais-Bird, R. Madden, E. R. Paquet, C. Koh, J. P. Venables, P. Prinos, et al.
Multiple Alternative Splicing Markers for Ovarian Cancer
Cancer Res.,
February 1, 2008;
68(3):
657 - 663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. H Thomas, R. S Ismail, J.-Y. Jiang, and B. C Vanderhyden
Kit Ligand 2 Promotes Murine Oocyte Growth In Vitro
Biol Reprod,
January 1, 2008;
78(1):
167 - 175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Li, J. Quirt, H. Q. Do, K. Lyte, F. Fellows, C. G. Goodyer, and R. Wang
Expression of c-Kit receptor tyrosine kinase and effect on beta-cell development in the human fetal pancreas
Am J Physiol Endocrinol Metab,
August 1, 2007;
293(2):
E475 - E483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Buza-Vidas, M. Cheng, S. Duarte, H. Nozad, S. E. W. Jacobsen, and E. Sitnicka
Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
Blood,
July 1, 2007;
110(1):
424 - 432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Dentelli, A. Rosso, A. Balsamo, S. Colmenares Benedetto, A. Zeoli, M. Pegoraro, G. Camussi, L. Pegoraro, and M. F. Brizzi
C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium
Blood,
May 15, 2007;
109(10):
4264 - 4271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-H. Jang, D. M. Herber, X. Jiang, S. Nandi, X.-M. Dai, G. Zeller, E. R. Stanley, and V. R. Kelley
Distinct In Vivo Roles of Colony-Stimulating Factor-1 Isoforms in Renal Inflammation
J. Immunol.,
September 15, 2006;
177(6):
4055 - 4063.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.J. Hutt, E.A. McLaughlin, and M.K. Holland
Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis
Mol. Hum. Reprod.,
February 1, 2006;
12(2):
61 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nandi, M. P. Akhter, M. F. Seifert, X.-M. Dai, and E. R. Stanley
Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain
Blood,
January 15, 2006;
107(2):
786 - 795.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. H. Hsieh, P. Sharma, A. Gibbons, T. Goggans, S. C. Erzurum, and S. J. Haque
Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells
PNAS,
October 4, 2005;
102(40):
14380 - 14385.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. H. Thomas, J.-F. Ethier, S. Shimasaki, and B. C. Vanderhyden
Follicle-Stimulating Hormone Regulates Oocyte Growth by Modulation of Expression of Oocyte and Granulosa Cell Factors
Endocrinology,
February 1, 2005;
146(2):
941 - 949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lennartsson, T. Jelacic, D. Linnekin, and R. Shivakrupa
Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit
Stem Cells,
January 1, 2005;
23(1):
16 - 43.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. K. Williamson, B. C. Dibling, J. R. Boyne, P. Selby, and S. A. Burchill
Basic Fibroblast Growth Factor-induced Cell Death Is Effected through Sustained Activation of p38MAPK and Up-regulation of the Death Receptor p75NTR
J. Biol. Chem.,
November 12, 2004;
279(46):
47912 - 47928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Bedell and A. M. Zama
Genetic Analysis of Kit Ligand Functions During Mouse Spermatogenesis
J Androl,
March 1, 2004;
25(2):
188 - 199.
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-M. Dai, X.-H. Zong, V. Sylvestre, and E. R. Stanley
Incomplete restoration of colony-stimulating factor 1 (CSF-1) function in CSF-1-deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1
Blood,
February 1, 2004;
103(3):
1114 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Gonzalez, E. J. Andreu, A. Panizo, S. Inoges, A. Fontalba, J. L. Fernandez-Luna, M. Gaboli, L. Sierrasesumaga, S. Martin-Algarra, J. Pardo, et al.
Imatinib Inhibits Proliferation of Ewing Tumor Cells Mediated by the Stem Cell Factor/KIT Receptor Pathway, and Sensitizes Cells to Vincristine and Doxorubicin-Induced Apoptosis
Clin. Cancer Res.,
January 15, 2004;
10(2):
751 - 761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chandra, R. Kapur, N. Chuzhanova, V. Summey, D. Prentice, J. Barker, D. N. Cooper, and D. A. Williams
A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype
Blood,
November 15, 2003;
102(10):
3548 - 3555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nano, E. Battaglia, G. Gasparri, L. Dughera, P. A. Casalegno, G. Bellone, D. Tibaudi, C. Gramigni, M. Ferronato, L. Chiusa, et al.
Decreased Expression of Stem Cell Factor in Esophageal and Gastric Mucosa After Esophagogastric Anastomosis for Cancer: Potential Relevance to Motility
Ann. Surg. Oncol.,
August 1, 2003;
10(7):
801 - 809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-Q. Yao, J.-J. Wu, B.-H. Sun, N. Troiano, M. A. Mitnick, and K. Insogna
The Cell Surface Form of Colony-Stimulating Factor-1 Is Biologically Active in Bone in Vivo
Endocrinology,
August 1, 2003;
144(8):
3677 - 3682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Piliponsky, G. J. Gleich, A. Nagler, I. Bar, and F. Levi-Schaffer
Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor
Blood,
March 1, 2003;
101(5):
1898 - 1904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rich, S. M. Miller, S. J. Gibbons, J. Malysz, J. H. Szurszewski, and G. Farrugia
Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture
Am J Physiol Gastrointest Liver Physiol,
February 1, 2003;
284(2):
G313 - G320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Rajaraman, W. S. Davis, A. Mahakali-Zama, H. K. Evans, L. B. Russell, and M. A. Bedell
An Allelic Series of Mutations in the Kit ligand Gene of Mice. I. Identification of Point Mutations in Seven Ethylnitrosourea-Induced KitlSteel Alleles
Genetics,
September 1, 2002;
162(1):
331 - 340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kapur, S. Chandra, R. Cooper, J. McCarthy, and D. A. Williams
Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor
Blood,
July 30, 2002;
100(4):
1287 - 1293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Anzai, Y. Lee, B.-S. Youn, S. Fukuda, Y.-J. Kim, C. Mantel, M. Akashi, and H. E. Broxmeyer
c-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors
Blood,
May 29, 2002;
99(12):
4413 - 4421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-L. Hartman, A. M. Piliponsky, V. Temkin, and F. Levi-Schaffer
Human peripheral blood eosinophils express stem cell factor
Blood,
February 15, 2001;
97(4):
1086 - 1091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Landuzzi, C. De Giovanni, G. Nicoletti, I. Rossi, C. Ricci, A. Astolfi, L. Scopece, K. Scotlandi, M. Serra, G. P. Bagnara, et al.
The Metastatic Ability of Ewing's Sarcoma Cells Is Modulated by Stem Cell Factor and by Its Receptor c-kit
Am. J. Pathol.,
December 1, 2000;
157(6):
2123 - 2131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Zandstra, D. A. Lauffenburger, and C. J. Eaves
A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis
Blood,
August 15, 2000;
96(4):
1215 - 1222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Liu, P. Tzou, R. J. Hill, and P. W. Sternberg
Structural Requirements for the Tissue-Specific and Tissue-General Functions of the Caenorhabditis elegans Epidermal Growth Factor LIN-3
Genetics,
November 1, 1999;
153(3):
1257 - 1269.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Kapur, R. Cooper, X. Xiao, M. J. Weiss, P. Donovan, and D. A. Williams
The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects in Steel17H Mice
Blood,
September 15, 1999;
94(6):
1915 - 1925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bennaceur-Griscelli, C. Tourino, B. Izac, W. Vainchenker, and L. Coulombel
Murine Stromal Cells Counteract the Loss of Long-Term Culture-Initiating Cell Potential Induced by Cytokines in CD34+CD38low/neg Human Bone Marrow Cells
Blood,
July 15, 1999;
94(2):
529 - 538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Erben, E. Thiel, and M. Notter
Differential Effects of a Stem Cell Factor-Immunoglobulin Fusion Protein on Malignant and Normal Hematopoietic Cells
Cancer Res.,
June 1, 1999;
59(12):
2924 - 2930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Leslie, J. O'Prey, C. Bartholomew, and P. R. Harrison
An Activating Mutation in the Kit Receptor Abolishes the Stroma Requirement for Growth of ELM Erythroleukemia Cells, But Does Not Prevent Their Differentiation in Response to Erythropoietin
Blood,
December 15, 1998;
92(12):
4798 - 4807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Povey, N. Weeratunge, C. Marden, A. Sehgal, A. Thrasher, and C. Casimir
Enhanced Retroviral Transduction of 5-Fluorouracil-Resistant Human Bone Marrow (Stem) Cells Using a Genetically Modified Packaging Cell Line
Blood,
December 1, 1998;
92(11):
4080 - 4089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. O'Prey, N. Leslie, K. Itoh, W. Ostertag, C. Bartholomew, and P. R. Harrison
Both Stroma and Stem Cell Factor Maintain Long-Term Growth of ELM Erythroleukemia Cells, but Only Stroma Prevents Erythroid Differentiation in Response to Erythropoietin and Interleukin-3
Blood,
March 1, 1998;
91(5):
1548 - 1555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Lyman and S. E. W. Jacobsen
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Blood,
February 15, 1998;
91(4):
1101 - 1134.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kapur, M. Majumdar, X. Xiao, M. McAndrews-Hill, K. Schindler, and D. A. Williams
Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in Erythropoiesis
Blood,
February 1, 1998;
91(3):
879 - 889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. C. Broudy, N. L. Lin, H.-J. Buhring, N. Komatsu, and T. J. Kavanagh
Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer
Blood,
February 1, 1998;
91(3):
898 - 906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Di Marco, I. Gloaguen, A. Demartis, I. Saggio, R. Graziani, G. Paonessa, and R. Laufer
Agonistic and Antagonistic Variants of Ciliary Neurotrophic Factor (CNTF) Reveal Functional Differences between Membrane-bound and Soluble CNTF alpha -Receptor
J. Biol. Chem.,
September 12, 1997;
272(37):
23069 - 23075.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Longley, L. Tyrrell, Y. Ma, D. A. Williams, R. Halaban, K. Langley, H. S. Lu, and N. M. Schechter
Chymase cleavage of stem cell factor yields a bioactive, soluble product
PNAS,
August 19, 1997;
94(17):
9017 - 9021.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. C. Broudy
Stem Cell Factor and Hematopoiesis
Blood,
August 15, 1997;
90(4):
1345 - 1364.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Miyoshi, S. Higashiyama, T. Nakagawa, N. Hayashi, and N. Taniguchi
Membrane-anchored Heparin-binding Epidermal Growth Factor-like Growth Factor Acts as a Tumor Survival Factor in a Hepatoma Cell Line
J. Biol. Chem.,
May 30, 1997;
272(22):
14349 - 14355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
