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Association and activation of Btk and Tec tyrosine kinases by gp130, a
signal transducer of the interleukin-6 family of cytokines
T Matsuda, M Takahashi-Tezuka, T Fukada, Y Okuyama, Y Fujitani, S Tsukada, H Mano, H Hirai, ON Witte and T Hirano
Division of Molecular Oncology, Osaka University Medical School, Japan.
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and
ciliary neurotrophic factor constitute the IL-6 family of cytokines and
play important roles in hematopoiesis, immune response, and nervous system.
The receptors for the IL-6 family of cytokines share gp130 through which
signals are generated, although the cytoplasmic region of gp130 does not
contain any catalytic domain. In this study we show that in addition to Jak
family tyrosine kinase, the stimulation of gp130 by IL-6 plus soluble IL-6
receptor alpha induced the activation of Btk and Tec tyrosine kinases,
whereas IL-3 and granulocyte colony-stimulating factor activated Tec but
not Btk in a pro-B cell line. Furthermore, both Btk and Tec kinases were
associated with gp130 without the ligand stimulation. Because Btk is a
critical tyrosine kinase for B lymphopoiesis and Tec is considered to be
involved in hematopoiesis, the results suggest the involvement of
gp130-Btk-Tec signal pathway in early lymphohematopoiesis.
Volume 85,
Issue 3,
pp. 627-633,
02/01/1995
Copyright © 1995 by The American Society of Hematology
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