|
|
 Previous Article | Table of Contents | Next Article 
Changes in the blood group Wright antigens are associated with a mutation
at amino acid 658 in human erythrocyte band 3: a site of interaction
between band 3 and glycophorin A under certain conditions [see comments]
LJ Bruce, SM Ring, DJ Anstee, ME Reid, S Wilkinson and MJ Tanner
Department of Biochemistry, School of Medical Sciences, University of
Bristol, UK.
The Wright (Wr) blood group antigens, Wra and Wrb, have been suggested to
be determined by alleles of the same gene. The Wrb antigen appears to
involve both red blood cell (RBC) band 3 and glycophorin A (GPA). We have
examined the cDNA sequences of the band 3 and GPA of one of the two known
Wr(a+b-) individuals. We show that this individual is homozygous for the
mutation Glu658-->Lys in band 3, but has normal GPA. Putative
heterozygotes with Wr(a+b+) RBCs have both Glu and Lys at residue 658 of
band 3, whereas the common Wr(a-b+) RBC phenotype only have band 3 with
Glu658. The Wra and Wrb antigens are determined by the amino acid at
residue 658 of band 3 and are antithetical. Examination of the amino acid
sequence and Wrb antigen expression of GPA-related hybrid glycophorins
suggests that Arg61 of GPA interacts with Glu658 of band 3 to form the Wrb
antigen. We suggest that the interaction is stabilized by the presence of
anti-Wrb antibodies and that this site of association between GPA and band
3 may be responsible for the previously reported ability of anti-GPA
antibodies to decrease the deformability of RBCs.
Volume 85,
Issue 2,
pp. 541-547,
01/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. M. Toye, R. C. Williamson, M. Khanfar, B. Bader-Meunier, T. Cynober, M. Thibault, G. Tchernia, M. Dechaux, J. Delaunay, and L. J. Bruce
Band 3 Courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild-type band 3 and glycophorin A
Blood,
June 1, 2008;
111(11):
5380 - 5389.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C.-M. Lee, J. A. Gimm, A. J. Lo, M. J. Koury, S. W. Krauss, N. Mohandas, and J. A. Chasis
Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivity
Blood,
March 1, 2004;
103(5):
1912 - 1919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bruce, R.-j. Pan, D. L. Cope, M. Uchikawa, R. B. Gunn, R. J. Cherry, and M. J. A. Tanner
Altered Structure and Anion Transport Properties of Band 3 (AE1, SLC4A1) in Human Red Cells Lacking Glycophorin A
J. Biol. Chem.,
January 23, 2004;
279(4):
2414 - 2420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Young and M. J. A. Tanner
Distinct Regions of Human Glycophorin A Enhance Human Red Cell Anion Exchanger (Band 3; AE1) Transport Function and Surface Trafficking
J. Biol. Chem.,
August 29, 2003;
278(35):
32954 - 32961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bruce, R. Beckmann, M. L. Ribeiro, L. L. Peters, J. A. Chasis, J. Delaunay, N. Mohandas, D. J. Anstee, and M. J.A. Tanner
A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
Blood,
May 15, 2003;
101(10):
4180 - 4188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. F. Wagner, J. Poole, and W. A. Flegel
Scianna antigens including Rd are expressed by ERMAP
Blood,
January 15, 2003;
101(2):
752 - 757.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sterling, B. V. Alvarez, and J. R. Casey
The Extracellular Component of a Transport Metabolon. EXTRACELLULAR LOOP 4 OF THE HUMAN AE1 Cl-/HCO3- EXCHANGER BINDS CARBONIC ANHYDRASE IV
J. Biol. Chem.,
July 5, 2002;
277(28):
25239 - 25246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Auffray, S. Marfatia, K. de Jong, G. Lee, C.-H. Huang, C. Paszty, M. J. A. Tanner, N. Mohandas, and J. A. Chasis
Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice
Blood,
May 1, 2001;
97(9):
2872 - 2878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Beckmann, J. S. Smythe, D. J. Anstee, and M. J. A. Tanner
Coexpression of band 3 mutants and Rh polypeptides: differential effects of band 3 on the expression of the Rh complex containing D polypeptide and the Rh complex containing CcEe polypeptide
Blood,
April 15, 2001;
97(8):
2496 - 2505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Jarolim, H.L. Rubin, D. Zakova, J. Storry, and M.E. Reid
Characterization of Seven Low Incidence Blood Group Antigens Carried by Erythrocyte Band 3 Protein
Blood,
December 15, 1998;
92(12):
4836 - 4843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Beckmann, J. S. Smythe, D. J. Anstee, and M. J.A. Tanner
Functional Cell Surface Expression of Band 3, the Human Red Blood Cell Anion Exchange Protein (AE1), in K562 Erythroleukemia Cells: Band 3 Enhances the Cell Surface Reactivity of Rh Antigens
Blood,
December 1, 1998;
92(11):
4428 - 4438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hassoun, T. Hanada, M. Lutchman, K. E. Sahr, J. Palek, M. Hanspal, and A. H. Chishti
Complete Deficiency of Glycophorin A in Red Blood Cells From Mice With Targeted Inactivation of the Band 3 (AE1) Gene
Blood,
March 15, 1998;
91(6):
2146 - 2151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Telen, M. Udani, M. K. Washington, M. C. Levesque, E. Lloyd, and N. Rao
A Blood Group-related Polymorphism of CD44 Abolishes a Hyaluronan-binding Consensus Sequence without Preventing Hyaluronan Binding
J. Biol. Chem.,
March 22, 1996;
271(12):
7147 - 7153.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
