|
|
 Previous Article | Table of Contents | Next Article 
The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes
and is developmentally regulated during myelomonocytic differentiation in
vivo
DC Link and M Zutter
Department of Medicine, Jewish Hospital at Washington University Medical
Center, St. Louis, MO 63110.
The proto-oncogene c-fgr is a member of the c-src gene family of
cytoplasmic tyrosine kinases. Previous studies have suggested that it is
normally expressed in neutrophils, monocytes, macrophages, and natural
killer cells. c-fgr is also expressed in the B cells of certain
lymphoproliferative disorders, namely, Epstein-Barr virus-associated
lymphoproliferative disease, and in chronic lymphocytic leukemia, but it
has not previously been detected in normal or reactive human lymphoid
tissue. In this study we have determined the pattern of p55c- fgr protein
expression in normal human hematopoietic and lymphoid tissues at the
single-cell level using immunohistochemical and immunofluorescent
techniques. We show that p55c-fgr expression is developmentally regulated
with high-level expression first evident at the myelocyte stage of myeloid
differentiation. In addition, we show that p55c-fgr is expressed in
circulating B lymphocytes isolated from chronic lymphocytic leukemia
patients but is not expressed in normal circulating B lymphocytes.
Surprisingly, p55c-fgr is also expressed in a subpopulation of normal B
lymphocytes, the mantle zone B lymphocytes. This demonstration that
p55c-fgr is expressed in a normal B-lymphocyte subpopulation suggests that
its expression in certain B-cell lymphoproliferative disorders may be an
indirect consequence of, rather than a primary cause of, the neoplastic
transformation process.
Volume 85,
Issue 2,
pp. 472-479,
01/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Zuccato, E. J. Blott, O. Holt, S. Sigismund, M. Shaw, G. Bossi, and G. M. Griffiths
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation
J. Cell Sci.,
January 1, 2007;
120(1):
191 - 199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-O. Kim, H.-S. Suh, Q. Si, B. I. Terman, and S. C. Lee
Anti-CD45RO Suppresses Human Immunodeficiency Virus Type 1 Replication in Microglia: Role of Hck Tyrosine Kinase and Implications for AIDS Dementia
J. Virol.,
January 1, 2006;
80(1):
62 - 72.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. K. Mirnics, E. Caudell, Y. Gao, K. Kuwahara, N. Sakaguchi, T. Kurosaki, J. Burnside, K. Mirnics, and S. J. Corey
Microarray Analysis of Lyn-Deficient B Cells Reveals Germinal Center-Associated Nuclear Protein and Other Genes Associated with the Lymphoid Germinal Center
J. Immunol.,
April 1, 2004;
172(7):
4133 - 4141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
