|
|
 Previous Article | Table of Contents | Next Article 
Differential regulation of macrophage differentiation in response to
leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of
enforced expression of the SCL transcription factor
T Tanigawa, N Nicola, GA McArthur, A Strasser and CG Begley
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne
Hospital, Victoria, Australia.
The physiologic program of macrophage differentiation normally proceeds in
a coordinated manner in response to several different growth factors.
Although the utilization of common receptor subunits may explain in part
overlapping biologic functions, mechanisms by which unique actions are
mediated remain obscure. We examined growth factor- induced macrophage
differentiation in M1 leukemia cells that simultaneously display receptors
for interleukin-6 (IL-6), leukemia inhibitory factor (LIF) and Oncostatin-M
(OSM). Differentiation induced by all three factors was associated with
decreased expression of transcription factors myb and SCL, increased
expression of macrophage markers, and suppression of proliferation. Cell
lines were established in which SCL expression was enforced. In the absence
of growth factors, cells were indistinguishable from parental cells.
However, LIF (or OSM)- induced macrophage differentiation was perturbed;
there was failure to undergo morphologic differentiation, disturbed
expression of lysozyme and Mac1 alpha, and failure to suppress
proliferation. Surprisingly the perturbation of macrophage differentiation
did not apply to induced expression of macrophage colony-stimulating factor
(M-CSF) or granulocyte colony stimulating factor (G-CSF) receptors. This
dissociation of elements normally coordinated in a macrophage
differentiation program applied at a clonal level. There was no disturbance
of IL-6-induced macrophage differentiation. These data directly implicate
SCL in components of the macrophage differentiation program (suggesting
that LIF receptor/gp130 heterodimers utilize an SCL- inhibitable pathway
while gp130 homodimers do not) and demonstrate differential-regulation of
components of the mature macrophage phenotype.
Volume 85,
Issue 2,
pp. 379-390,
01/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Hams, C. S. Colmont, V. Dioszeghy, V. J. Hammond, C. A. Fielding, A. S. Williams, M. Tanaka, A. Miyajima, P. R. Taylor, N. Topley, et al.
Oncostatin M Receptor-{beta} Signaling Limits Monocytic Cell Recruitment in Acute Inflammation
J. Immunol.,
August 1, 2008;
181(3):
2174 - 2180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Hamilton, G. Whitty, P. Masendycz, N. J. Wilson, J. Jackson, D. De Nardo, and G. M. Scholz
The Critical Role of the Colony-Stimulating Factor-1 Receptor in the Differentiation of Myeloblastic Leukemia Cells
Mol. Cancer Res.,
March 1, 2008;
6(3):
458 - 467.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ravet, D. Reynaud, M. Titeux, B. Izac, S. Fichelson, P.-H. Romeo, A. Dubart-Kupperschmitt, and F. Pflumio
Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis
Blood,
May 1, 2004;
103(9):
3326 - 3335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Auernhammer and S. Melmed
Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function
Endocr. Rev.,
June 1, 2000;
21(3):
313 - 345.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. M. Hermanns, S. Radtke, C. Haan, H. Schmitz-Van de Leur, J. Tavernier, P. C. Heinrich, and I. Behrmann
Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130
J. Immunol.,
December 15, 1999;
163(12):
6651 - 6658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Elefanty, C. G. Begley, L. Hartley, B. Papaevangeliou, and L. Robb
SCL Expression in the Mouse Embryo Detected With a Targeted lacZ Reporter Gene Demonstrates Its Localization to Hematopoietic, Vascular, and Neural Tissues
Blood,
December 1, 1999;
94(11):
3754 - 3763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Begley and A. R. Green
The SCL Gene: From Case Report to Critical Hematopoietic Regulator
Blood,
May 1, 1999;
93(9):
2760 - 2770.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Elwood, H. Zogos, D. S. Pereira, J. E. Dick, and C. G. Begley
Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL
Blood,
May 15, 1998;
91(10):
3756 - 3765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Curtis, D. J. Hilton, B. Roberts, L. Murray, N. Nicola, and C. G. Begley
Recombinant Soluble Interleukin-11 (IL-11) Receptor alpha -Chain Can Act as an IL-11 Antagonist
Blood,
December 1, 1997;
90(11):
4403 - 4412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kodama, K. Fukuda, J. Pan, S. Makino, A. Baba, S. Hori, and S. Ogawa
Leukemia Inhibitory Factor, a Potent Cardiac Hypertrophic Cytokine, Activates the JAK/STAT Pathway in Rat Cardiomyocytes
Circ. Res.,
November 19, 1997;
81(5):
656 - 663.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M.-Y. Zhang, G. A. Clawson, N. F. Olivieri, L. L. Bell, C. G. Begley, and B. A. Miller
Expression of SCL Is Normal in Transfusion-Dependent Diamond-Blackfan Anemia But Other bHLH Proteins Are Deficient
Blood,
September 1, 1997;
90(5):
2068 - 2074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Starr, U. Novak, T. A. Willson, M. Inglese, V. Murphy, W. S. Alexander, D. Metcalf, N. A. Nicola, D. J. Hilton, and M. Ernst
Distinct Roles for Leukemia Inhibitory Factor Receptor alpha -Chain and gp130 in Cell Type-specific Signal Transduction
J. Biol. Chem.,
August 8, 1997;
272(32):
19982 - 19986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Nicholson, R. Starr, U. Novak, D. J. Hilton, and J. E. Layton
Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells
J. Biol. Chem.,
October 25, 1996;
271(43):
26947 - 26953.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Sayer, P. A. Tilbrook, A. Spadaccini, E. Ingley, M. K. Sarna, J. H. Williams, N. C. Andrews, and S. P. Klinken
Ectopic Expression of Transcription Factor NF-E2 Alters the Phenotype of Erythroid and Monoblastoid Cells
J. Biol. Chem.,
August 11, 2000;
275(33):
25292 - 25298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
