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Advances in the biology and treatment of B-cell chronic lymphocytic
leukemia
S O'Brien, A del Giglio and M Keating
Department of Hematology, University of Texas M.D. Anderson Cancer Center,
Houston 77030.
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in
the western hemisphere. Diagnosis and staging of CLL are usually
straightforward, but predicting an individual patient's prognosis is still
a challenge. Cytogenetic abnormalities provide important prognostic
information in CLL and may show its molecular heterogeneity. A search for
oncogene abnormalities continues, although no consistent defects have been
identified. New agents such as fludarabine produce high complete remission
rates and have generated interest in earlier treatment as a first step in a
potential cure. Fludarabine also makes autologous bone marrow transplant
feasible as a consolidation therapy. Immunologic abnormalities and minimal
residual disease persist in most patients in remission. Combining
fludarabine with other active agents and devising effective postremission
strategies may change the natural history of CLL.
Volume 85,
Issue 2,
pp. 307-318,
01/15/1995
Copyright © 1995 by The American Society of Hematology
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