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Interleukin-10 is an autocrine growth factor for acquired immunodeficiency
syndrome-related B-cell lymphoma [see comments]
R Masood, Y Zhang, MW Bond, DT Scadden, T Moudgil, RE Law, MH Kaplan, B Jung, BM Espina and Y Lunardi-Iskandar
Department of Medicine, University of Southern California, Norris Cancer
Hospital and Research Institute, Los Angeles 90033, USA.
Interleukin-10 (IL-10) is an acid-sensitive protein of 35 kD that has
pleiotropic effects including inhibition of cytotoxic T-cell response,
induction of major histocompatibility complex type II in B lymphocytes,
induction of B-cell growth and differentiation, and autocrine growth factor
activity in monocytes. We and others have shown that IL-10 is produced
spontaneously by blood mononuclear cells from human immunodeficiency
virus-seropositive patients. In an attempt to ascertain the potential role
of IL-10 in acquired immunodeficiency syndrome (AIDS)-related B-cell
lymphoma, we evaluated the expression of human IL-10 in both tumor-derived
B-cell lines and primary tumor cells. Expression of human IL-10 (hIL-10)
mRNA and protein was detected in four of five cell lines examined. An IL-10
antisense oligonucleotide inhibited IL-10 mRNA expression and IL-10 protein
production. The proliferation of all B-cell lines was inhibited by an
antisense oligonucleotide in a dose-dependent manner that was abrogated by
the addition of recombinant hIL-10 protein. No effect of antisense
oligonucleotide was observed in the B-cell line not producing hIL-10.
Evaluation of primary tumor cells from patients with AIDS-lymphoma cells
showed similar production and response to IL-10. These data suggest an
autocrine growth mechanism for IL-10 in AIDS-related lymphoma cells and
that IL-10 may be important in its pathogenesis.
Volume 85,
Issue 12,
pp. 3423-3430,
06/15/1995
Copyright © 1995 by The American Society of Hematology
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