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Analysis of the human CD10/neutral endopeptidase 24.11 promoter region: two
separate regulatory elements
F Ishimaru and MA Shipp
Department of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115,
USA.
The cell surface zinc metalloproteinase CD10/neutral endopeptidase 24.11
(NEP) is expressed on normal and malignant lymphoid progenitors,
granulocytes, and a variety of epithelial cells. To further define the
tissue-specific and developmentally related expression of CD10/NEP, we have
characterized two separate regulatory regions that control the
transcription of 5' alternatively spliced CD10/NEP transcripts. These type
1 and 2 CD10/NEP regulatory regions are both characterized by the presence
of multiple transcription initiation sites and the absence of classic TATA
boxes and consensus initiator elements. The purine-rich type 1 regulatory
region, which includes 5' UTR exon 1 sequence, is characterized by multiple
putative PU.1 binding sites and consensus ets- binding motifs. In marked
contrast, the GC-rich type 2 regulatory region contains multiple putative
Sp1 binding sites, a potential consensus retinoblastoma control element
(RCE), and an inverted CCAAT box. In the majority of tissues examined to
date, type 2 CD10/NEP transcripts were more abundant; the abundance of type
1 transcripts was more variable, with the highest type 1 levels in fetal
thymus and certain lymphoblastic leukemia cell lines.
Volume 85,
Issue 11,
pp. 3199-3207,
06/01/1995
Copyright © 1995 by The American Society of Hematology
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