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Absence of the t(2;5) in Hodgkin's disease [see comments]
LM Weiss, JR Lopategui, LH Sun, OW Kamel, CH Koo and C Glackin
Department of Pathology, City of Hope National Medical Center, Duarte, CA
91010, USA.
The cytogenetics of Hodgkin's disease (HD) is poorly understood. However, a
t(2;5) is a common finding in CD30+ anaplastic large cell lymphoma (ALCL),
a neoplasm thought by some to be closely related to HD. Recently, the
t(2;5) has been cloned and found to represent fusion of the NPM gene with
the ALK gene. Using Southern blot hybridization, one group has reported
finding rearrangements of NPM in a proportion of cases of both ALCL and HD.
In the current study, we used a highly sensitive reverse
transcriptase-polymerase chain reaction methodology to analyze 34 cases of
HD for the t(2;5). We were unable to find polymerase chain reaction
evidence for the t(2;5) in any of the cases of HD, a result significantly
different from our previous study of CD30+ non-Hodgkin's lymphomas (P <
.02) including ALCL (P < .04), using identical methods. Our results do
not support the hypothesis that the t(2;5) represents a common chromosomal
abnormality for both HD and ALCL.
Volume 85,
Issue 10,
pp. 2845-2847,
05/15/1995
Copyright © 1995 by The American Society of Hematology
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