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High expression of the bcl-x gene in Reed-Sternberg cells of Hodgkin's
disease
D Schlaifer, M March, S Krajewski, G Laurent, J Pris, G Delsol, JC Reed and P Brousset
Service d'Hematologie, Clinique Dieulafoy, Hopital de Purpan, Toulouse,
France.
The expression of bcl-x protein, a bcl-2-related protein present in
cortical thymocytes, activated lymphocytes, and plasma cells of reactive
lymph nodes, was investigated in 44 cases of Hodgkin's disease (HD) in
parallel with bcl-2 and Epstein-Barr virus (EBV) status. Eighty- six
percent of the cases were positive for bcl-x, among them 27% with a strong
signal in more than 75% of the Reed-Sternberg cells. Positivity for bcl-x
was found in, respectively, 100% and 92% of the nodular sclerosis and mixed
cellularity subtypes, although 4 cases of lymphocyte predominance subtype
were negative. This finding was in contrast with the weaker positivity for
bcl-2 staining in 44% of the cases. EBV small RNAs were detected in 43% of
the cases by using in situ hybridization. Of interest, 100% of the
EBV-positive samples were positive for bcl-x, whereas only 38% of these
cases were bcl-2 positive. Our findings show that the bcl-x gene expression
is high in HD, suggesting that bcl-x may have a role in the pathogenesis of
at least some cases of HD via apoptosis regulation.
Volume 85,
Issue 10,
pp. 2671-2674,
05/15/1995
Copyright © 1995 by The American Society of Hematology
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