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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stickney, D. Articles by Klein, J. Search for Related Content PubMed PubMed Citation Articles by Stickney, D. Articles by Klein, J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Heat-stable antigen may be an early marker of extrathymic murine intestinal intraepithelial lymphocytes DG Stickney, J Wang, M Hamad and JR Klein Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, OK. Using a system of bone marrow (BM) hematopoietic repopulation of irradiated euthymic and athymic mice, we have examined the early stages of extrathymic T-cell development within the murine small intestine epithelium. During a period of active extrathymic T-cell development, two distinct populations of intraepithelial lymphocytes (IEL) were present. One consisted of CD3+ lymphocytes with phenotypic properties of mature IEL. The other population consisted of a transient IEL subset that increased in abundance between days 5 and 14 post-BM transfer, and then declined. The majority of transient IEL in both types of mice expressed the heat-stable antigen, of which some cells coexpressed CD3 but were void of other markers common to mature T cells. Studies using freshly extracted IEL from normal nonirradiated mice found that approximately 3% to 5% of the IEL had phenotypic properties similar to the transient IEL observed during repopulation of radiation chimeras, indicating that such IEL are present within the gut epithelium of normal, nonirradiated mice. Identification of this IEL subset should greatly facilitate studies of extrathymic IEL development. Volume 84, Issue 9, pp. 3034-3039, 11/01/1994 Copyright © 1994 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Wang, M. Whetsell, and J. R. Klein Local Hormone Networks and Intestinal T Cell Homeostasis Science, March 28, 1997; 275(5308): 1937 - 1939. [Abstract] [Full Text]

	Copyright © 1994 by American Society of Hematology         Online ISSN: 1528-0020