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Effects of in vivo recombinant methionyl human granulocyte colony-
stimulating factor on the neutrophil response and peripheral blood
colony-forming cells in healthy young and elderly adult volunteers
GS Chatta, TH Price, RC Allen and DC Dale
Department of Medicine, University of Washington, Puget Sound Blood Center,
Seattle.
Recombinant granulocyte colony stimulating factor (G-CSF) was administered
daily for 14 days to healthy young (Y) (20 to 30 years) and elderly (O) (70
to 80 years) volunteers to evaluate the effects of age on the neutrophil
(polymorphonuclear leukocytes, PMN) responses. Thirty-eight volunteers were
randomized to receive 0 micrograms, 30 micrograms, or 300 micrograms per
day. Baseline neutrophil counts (ANC), peak ANCs, and the rate of attaining
the peak ANC were similar in both age groups at both doses. The peak ANC
was increased 5-fold at 30 micrograms and 15-fold at 300 micrograms in both
the young and elderly. Daily tests of PMN function, as measured by an
automated chemiluminescence system, showed nearly identical responses to
several agonists for both age groups. Marrow proliferative activity as
reflected by the percentage of cells in the marrow neutrophil mitotic pool
also increased similarly for both age groups at both doses. In contrast,
there was an age-related change in blood colony formation as measured by
the blood CFU-GM assay. Compared with controls at the 30 micrograms dose,
mean colony formation was increased 2-fold in the young versus no change in
the elderly and at the 300 micrograms dose 24- fold in the young versus
12-fold in the elderly. These studies indicate that neutrophil responses to
rhG-CSF are equivalent in healthy young and elderly volunteers but the
mobilization of progenitor cells, as measured by the CFU-GM assay appears
to differ substantially.
Volume 84,
Issue 9,
pp. 2923-2929,
11/01/1994
Copyright © 1994 by The American Society of Hematology
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