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Detection of aberrant clones in nearly all cases of angioimmunoblastic
lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined
interphase and metaphase cytogenetics
B Schlegelberger, Y Zhang, K Weber-Matthiesen and W Grote
Department of Human Genetics, University of Kiel, Germany.
Trisomy 3, trisomy 5, and an X additional chromosome are the most frequent
chromosome aberrations in angioimmunoblastic lymphadenopathy with
proteinemia (AILD)-type T-cell lymphomas. To evaluate the frequency of +3
and +X clones, fluorescence in situ hybridization studies with
centromere-specific probes for chromosome 3 and X were done in 41 patients
with peripheral T-cell lymphomas (PTL). With this interphase cytogenetic
approach, 32 of 41 patients (78%) showed +3 clones, and 14 patients (34%)
+X clones. These frequencies far exceeded those observed with metaphase
cytogenetics (+3, 41%; +X, 20%). Summing up the results of metaphase and
interphase cytogenetics, aberrant clones were found in 37 of 41 patients
with PTL (90%) and 32 of 36 patients with AILD-type T-cell lymphoma (89%).
Although AILD-type T- cell lymphoma is considered a neoplastic disease, it
is an exception in that it shows a high frequency of cytogenetically
unrelated clones and single cells that cannot be derived from a common cell
of origin because of their completely different karyotypes. In five
patients, double hybridization with centromere-specific probes for
chromosomes 3 and X showed that these aberrations occurred in different
cells. When the results of metaphase and interphase cytogenetics were
combined, 17 of 36 patients with AILD-type T-cell lymphoma (47%) had
unrelated clones. This high frequency of oligoclonal proliferations may be
caused by increased genetic instability and an immune defect resulting in
impaired elimination of aberrant cells.
Volume 84,
Issue 8,
pp. 2640-2648,
10/15/1994
Copyright © 1994 by The American Society of Hematology
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