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Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and
preferential deletion of 1p in 21 patients with multiple myeloma and plasma
cell leukemia
M Taniwaki, K Nishida, T Takashima, H Nakagawa, H Fujii, T Tamaki, C Shimazaki, S Horiike, S Misawa and T Abe
Third Department of Internal Medicine, Kyoto Prefectural University of
Medicine, Japan.
Structural chromosomal abnormalities and their break-points were
characterized in 17 patients with multiple myeloma (MM) and 4 with plasma
cell leukemia by banding. Chromosome 14q32 translocations with a variety of
partners were detected in 13 patients, and a variant translocation
t(8;22)(q24.1;q11) was detected in 1. Three recurrent 14q32 translocations
have been identified: t(6;14)(p21.1;q32.3) occurring in 3 cases, and
t(11;14)(q13;q32.3) and t(14;18) (q32.3;q21.3) each occurring in 2 cases.
Translocations t(1;14)(q21;q32.3), t(3;14)(p11;q32),t(7;14)(q11.2;q32.3),
and t(11;14)(q23;q32.3) were found in each patient, whereas in the
remaining 2 patients, partner chromosomes could not be determined. The band
19p13.3 was newly delineated as a recurrent breakpoint involved in
translocations in MM. Chromosomes 1 and 6 were also commonly involved in
structural abnormalities (14 and 10 patients, respectively), although no
particular bands were noted. However, the short arm of chromosome 1 was
preferentially involved in deletion, suggesting a certain antioncogene on
1p associated with the development of myeloma. In addition; fluorescence in
situ hybridization was successfully applied to determine the nature of the
structural abnormalities in a patient with t(8;22) translocation. The
present findings suggest that there may be subsets of 14q32 translocations
specific to MM.
Volume 84,
Issue 7,
pp. 2283-2290,
10/01/1994
Copyright © 1994 by The American Society of Hematology
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