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Interleukin-13 inhibits the proliferation of normal and leukemic human
B-cell precursors
N Renard, V Duvert, J Banchereau and S Saeland
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
Interleukin-13 (IL-13) is a T-cell-derived cytokine that displays homology
with IL-4 and shares some of its biologic functions. We investigated the
effects of IL-13 on normal human B-cell precursors (BCP) and their
malignant counterparts in B-lineage acute lymphoblastic leukemia (BCP-ALL).
IL-13 inhibited growth of CD19+ slg- normal BCP cultured in the presence or
absence of bone marrow accessory stromal cells and IL-7. In addition, IL-13
inhibited proliferation of blasts isolated from leukemic patients and cells
from established BCP-ALL lines. Differences were observed in a number of
cases with respect to growth inhibition in response to IL-13 and IL-4.
These results suggest heterogeneity in the expression of IL-13 and IL-4
receptors in B-cell ontogeny. Growth-inhibition by IL-13 could be reverted
by anti-IL-4 receptor antibody, indicating that the IL-13 and IL-4 binding
chains can be closely associated on BCP. We further showed that the
inhibitory effect of IL-13 results from decreased cell-cycle activity.
Finally, whereas IL-13 induced CD23 expression on BCP-ALL cells, it did not
promote differentiation into slg+ B lymphocytes.
Volume 84,
Issue 7,
pp. 2253-2260,
10/01/1994
Copyright © 1994 by The American Society of Hematology
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