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Histamine induces interleukin-8 secretion by endothelial cells
P Jeannin, Y Delneste, P Gosset, S Molet, P Lassalle, Q Hamid, A Tsicopoulos and AB Tonnel
Pathologie Immuno-Allergique Respiratoire et Cellules Inflammatoires,
INSERM U-416, Institut Pasteur, Lille, France.
It has been shown that histamine induces early changes on endothelial cells
(EC), such as a transient expression of P-selectin and secretion and/or
surface expression of early mediators (eg, prostacyclin [PG1(2)],
platelet-activating factor [PAF], and leukotriene B4 [LTB4]). However,
delayed effects of histamine on EC and particularly on cytokine production
are undefined. In this study, the effect of histamine on interleukin (IL)-8
production by EC was evaluated using an enzyme-linked immunosorbent assay
(ELISA) method and mRNA expression. The results showed that histamine
increased the secretion and the mRNA expression of IL-8 by EC.
Histamine-induced IL-8 production was (1) dose-dependent (at a dose > or
= 10(-6) mol/L), (2) potentialized by costimulation with tumor necrosis
factor (TNF)-alpha, (3) inhibited by H1 or H2 histamine receptor
antagonists, and (4) significantly increased 4 hours after the initial
stimulation. These data suggest that histamine may be involved in the
control of the late inflammatory reaction associated to allergic disorders
through IL-8 secretion by EC.
Volume 84,
Issue 7,
pp. 2229-2233,
10/01/1994
Copyright © 1994 by The American Society of Hematology
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