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Leukocyte-endothelial adhesion molecules
TM Carlos and JM Harlan
Department of Medicine (Hematology/BMT), University of Pittsburgh Medical
Center, PA 15213-2582.
In the 9 years since the last review on leukocyte and endothelial
interactions was published in this journal many of the critical structures
involved in leukocyte adherence to and migration across endothelium have
been elucidated. With the advent of cell and molecular biology approaches,
investigations have progressed from the early descriptions by intravital
microscopy and histology, to functional and immunologic characterization of
adhesion molecules, and now to the development of genetically deficient
animals and the first phase I trial of "anti-adhesion" therapy in humans.
The molecular cloning and definition of the adhesive functions of the
leukocyte integrins, endothelial members of the Ig gene superfamily, and
the selectins has already provided sufficient information to construct an
operative paradigm of the molecular basis of leukocyte emigration. The
regulation of these adhesion molecules by chemoattractants, cytokines, or
chemokines, and the interrelationships of adhesion pathways need to be
examined in vitro and, particularly, in vivo. Additional studies are
required to dissect the contribution of the individual adhesion molecules
to leukocyte emigration in various models of inflammation or immune
reaction. Certainly, new adhesion structures will be identified, and the
current paradigm of leukocyte emigration will be refined. The promise of
new insights into the biology and pathology of the inflammatory and immune
response, and the potential for new therapies for a wide variety of
diseases assures that this will continue to be an exciting area of
investigation.
Volume 84,
Issue 7,
pp. 2068-2101,
10/01/1994
Copyright © 1994 by The American Society of Hematology
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