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Expression of axl, a transforming receptor tyrosine kinase, in normal and
malignant hematopoiesis
A Neubauer, A Fiebeler, DK Graham, JP O'Bryan, CA Schmidt, P Barckow, S Serke, W Siegert, HR Snodgrass and D Huhn
We previously reported the cloning, and characterization of a receptor
tyrosine kinase, axl, from two patients with chronic myelogenous leukemia.
Herein, we describe the expression pattern of axl in normal and malignant
hematopoietic tissue axl message is detected in normal human bone marrow
but not significantly in normal blood leukocytes. Cell separation
experiments showed that axl is expressed in hematopoietic CD34+ progenitor
and marrow stromal cells, at low levels in peripheral monocytes, but not in
lymphocytes or granulocytes. Consistent with the normal pattern of axl
expression, axl RNA was found predominantly in diseases of the myeloid
lineage: 39 of 66 (59%) patients with myeloproliferative disorders (acute
myeloid leukemia, chronic myeloid leukemia (CML) in chronic phase, CML in
myeloid blast crisis, and myelodysplasia) showed significant axl
transcription, as compared with 1 of 45 (2%) lymphoid leukemias (chronic
lymphocytic leukemia, acute lymphocytic leukemia, and CML in lymphoid blast
crisis). Treatment of K562 cells with the phorbol ester, 12-O-
tetradecanoylphorbol-13-acetate (TPA), administration of interferon alpha
(IFN alpha) to normal monocytes, and treatment of U937 cells with TPA and
IFN tau significantly induced axl expression, supporting a role for this
kinase in the intracellular signaling of myeloid cells through a variety of
biochemical pathways. These results suggest that the axl kinase may be
operative in normal and malignant myeloid biology.
Volume 84,
Issue 6,
pp. 1931-1941,
09/15/1994
Copyright © 1994 by The American Society of Hematology
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80(20):
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|
|
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|
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|
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272(47):
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|
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