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Regulation of endothelial and mesothelial cell function by interleukin- 13:
selective induction of vascular cell adhesion molecule-1 and amplification
of interleukin-6 production
M Sironi, FL Sciacca, C Matteucci, M Conni, A Vecchi, S Bernasconi, A Minty, D Caput, P Ferrara and F Colotta
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
The present study was designed to explore the interaction of interleukin-13
(IL-13) with vascular endothelial cells (EC). In vitro exposure to IL-13 of
human umbilical vein EC induced surface expression of vascular cell
adhesion molecule-1 (VCAM-1). At optimal concentrations (10 to 50 ng/mL)
and exposure times (24 hours), IL-13 was a twofold to threefold less
effective inducer of VCAM-1 than IL-1, which was used as reference EC
activator. When IL-13 was combined with IL-1, an almost additive induction
of VCAM-1 was observed. Induction of VCAM-1 by IL-13 was selective in that
E-selectin and intercellular adhesion molecule-1 (ICAM-1) were unaffected.
IL-13 caused a modest reduction of IL-1 induction of E-selectin and ICAM-1.
Surface expression of VCAM-1 on IL-13-treated cells was associated with
mRNA induction (as assessed by Northern analysis and reverse transcriptase-
polymerase chain reaction), with predominance of transcripts encoding the 7
Ig domain form of this molecule. In agreement with previous reports, IL-13
inhibited cytokine production in human monocytes. In contrast, IL-13 was a
weak inducer and an amplifier (in concert with IL- 1) of IL-6 expression in
EC. Mesothelial cells, which share properties with EC and regulate the
traffic and function of leukocytes in serosal cavities, were stimulated to
express VCAM-1 and IL-6 by IL-13. Thus, IL- 13 elicits a spectrum of
responses in vascular endothelium remarkably similar to that of IL-4 and
IL-10. Interaction of these cytokines with vascular endothelium may play an
important role in the induction and expression of Th2-dependent responses.
Volume 84,
Issue 6,
pp. 1913-1921,
09/15/1994
Copyright © 1994 by The American Society of Hematology
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180(4):
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|
|
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[Full Text]
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|
|
|
|
|
|
|
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|
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|
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|
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|
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113(6):
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[PDF]
|
|
|
|
|
|
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October 15, 1999;
274(42):
29944 - 29950.
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[Full Text]
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|
|
|
|
|
|
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|
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|
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163(3):
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|
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|
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51(2):
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|
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20(3):
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|
|
|
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|
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|
|
|
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J. Biol. Chem.,
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272(9):
5487 - 5494.
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[Full Text]
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|
|
|
|
|
|
|
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270(28):
16775 - 16780.
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|
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