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The B7-2 (B70) costimulatory molecule expressed by monocytes and activated
B lymphocytes is the CD86 differentiation antigen
P Engel, JG Gribben, GJ Freeman, LJ Zhou, Y Nozawa, M Abe, LM Nadler, H Wakasa and TF Tedder
Department of Immunology, Duke University Medical Center, Durham, NC 27710.
T-cell activation is initiated after T-cell receptor binding to antigen,
but also requires interactions between costimulatory molecules expressed on
antigen-presenting cells. An important costimulatory molecule expressed by
monocytes and activated B lymphocytes has been recently identified and
termed B7-2 or B70. Independently, a new Cluster of Differentiation was
defined in the Fifth International Leukocyte Differentiation Antigen
Workshop as CD86, a molecule predominantly expressed by monocytes and
activated B lymphocytes. In this study, the two monoclonal antibodies that
defined CD86, FUN-1 and BU-63, were shown to bind to cDNA transfected cells
expressing B7- 2/B70. The FUN-1 monoclonal antibody also completely blocked
the costimulatory activity of B7-2/B70 in functional assays. Therefore, the
serologically defined CD86 differentiation antigen is the B7-2/B70
molecule.
Volume 84,
Issue 5,
pp. 1402-1407,
09/01/1994
Copyright © 1994 by The American Society of Hematology
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