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A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as
the BCL-1 gene
H Komatsu, S Iida, K Yamamoto, C Mikuni, M Nitta, T Takahashi, R Ueda and M Seto
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya,
Japan.
The 11q13 breakpoint region of t(11;14) (q13;q32), translocated to the Ig
heavy chain locus at 14q32, has been designated as BCL-1 for B-cell
leukemia/lymphoma-1, but the nature of the transcriptional unit has long
remained unclear. Recently, the PRAD1 gene encoding cyclin D1, isolated
from the 11q13 region, was proposed as a candidate BCL-1 gene on the basis
of chromosome walking and concordant overexpression of PRAD1 mRNA in cell
lines with t(11;14)(q13;q32). We report here molecular analysis of a
variant translocation at the BCL-1 locus, t(11;22)(q13;q11), showing
juxtaposition of the Ig light chain gene, Ig lambda, to the PRAD1 gene at
its 3' end, resulting in overexpression of PRAD1 mRNA. Because only the
PRAD1 gene is present between the Ig heavy chain and light chain gene
breakpoints, an identity between BCL-1 and the PRAD1/cyclin D1 gene is
strongly indicated.
Volume 84,
Issue 4,
pp. 1226-1231,
08/15/1994
Copyright © 1994 by The American Society of Hematology
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