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Differential expression of bcl-2 and susceptibility to anti-Fas- mediated
cell death in peripheral blood lymphocytes, monocytes, and neutrophils
K Iwai, T Miyawaki, T Takizawa, A Konno, K Ohta, A Yachie, H Seki and N Taniguchi
Department of Pediatrics, School of Medicine, Kanazawa University,
Ishikawa, Japan.
The recently identified Fas antigen (Ag) is a cell surface molecule that
can mediate apoptosis. The cytoplasmic product of proto-oncogene bcl-2 has
been shown to prolong the cellular survival by inhibiting apoptosis. To
elucidate the physiologic significance of expression of both molecules, we
examined the expression of Fas Ag and bcl-2 on blood leukocyte populations
and evaluated their sensitivity to the cytolytic action of anti-Fas
antibody. Although Fas Ag was expressed on a fraction of lymphocytes, both
neutrophils and monocytes expressed Fas Ag constitutively. In contrast,
there was marked difference among these leukocytes regarding bcl-2
expression. Lymphocytes expressed bcl-2 intensely, but monocytes showed
weaker bcl-2 expression, and neutrophils were essentially absent for bcl-2
expression. Seemingly reflecting this lack of bcl-2-expression, neutrophils
more easily underwent apoptotic cell death in vitro as compared with
monocytes and lymphocytes. We showed that anti-Fas antibody affectively
accelerated apoptotic cell death in neutrophils. However, the
apoptosis-inducing effect of anti-Fas antibody was minimal on monocytes,
and lymphocytes were resistant to this antibody. These results suggest that
anti-Fas- mediated cell death may, in part, be determined by bcl-2
expression status in Fas+ lymphoid and hematopoietic cells.
Volume 84,
Issue 4,
pp. 1201-1208,
08/15/1994
Copyright © 1994 by The American Society of Hematology
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