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Mutations in the coding region of c-myc occur frequently in acquired
immunodeficiency syndrome-associated lymphomas
K Bhatia, G Spangler, G Gaidano, N Hamdy, R Dalla-Favera and I Magrath
Lymphoma Biology Section, National Cancer Institute, National Institutes of
Health, Bethesda, MD 20892.
We have analyzed 30 cases of high- and intermediate-grade acquired
immunodeficiency syndrome-associated non-Hodgkin's lymphoma (AIDS-NHL) for
mutations in the c-myc coding region. In addition, in these same tumors, we
have sought the presence of mutations in a regulatory region within the
first c-myc intron defined by the binding to a factor that inhibits c-myc
transcription (MYC intron factor, or mif). Mutations in the c-myc coding
region were present in 10 of 16 small noncleaved cell lymphoma (SNCL), but
in only 3 of 14 other histologic subtypes tested (0/3 large non-cleaved
cell, 2/8 immunoblastic, and 1/3 anaplastic large cell lymphomas). Nineteen
of the AIDS-NHLs analyzed contained a c- myc rearrangement and in 10 of
these the c-myc gene was mutated in its coding region. In contrast, we
could detect a mutation in the coding region in only 2 of 8 AIDS-NHL
without a c-myc rearrangement. Mutations in the mif region were detected in
5 of 16 SNCL. Among AIDS-NHL carrying mutations in the c-myc coding region,
only 4 carried mutations in the regulatory region. These results suggest
that the mutations in the coding region of the c-myc protein may either be
a consequence of the translocations involving c-myc, or may be necessary
only in tumors where c-myc is deregulated as a result of a c-myc/lg
translocation.
Volume 84,
Issue 3,
pp. 883-888,
08/01/1994
Copyright © 1994 by The American Society of Hematology
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