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Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe
combined immunodeficiency
FM Uckun, JR Downing, LM Chelstrom, R Gunther, M Ryan, J Simon, AJ Carroll, L Tuel-Ahlgren and WM Crist
Department of Therapeutic Radiology-Radiation Oncology, University of
Minnesota, Minneapolis 55455.
Mice with severe combined immunodeficiency (SCID) were injected
intravenously with primary bone marrow blasts from 12 children with newly
diagnosed t(4;11)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from
eight patients caused overt disseminated leukemia, whereas blasts from the
other four patients produced occult leukemia that was detectable only by
the polymerase chain reaction (PCR) technique. Only one patient among eight
whose blasts caused disseminated leukemia in SCID mice remains alive and
disease-free at 48.4 months postdiagnosis. In contrast, three of the other
four patients whose blasts did not cause overt leukemia in SCID mice remain
alive and disease-free at 6.1, 23.6, and 35.9 months, respectively. Thus,
the occurrence of overt leukemia in SCID mice may be a predictor of
patients' disease-free survival. The described SCID mouse model system may
prove useful for designing more effective treatment strategies against
therapy- refractory t(4;11) ALL.
Volume 84,
Issue 3,
pp. 859-865,
08/01/1994
Copyright © 1994 by The American Society of Hematology
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