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Expression of the G-protein--coupled receptor BLR1 defines mature,
recirculating B cells and a subset of T-helper memory cells
R Forster, T Emrich, E Kremmer and M Lipp
Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany.
The G-protein-coupled receptor BLR1 related to receptors for chemokines and
neuropeptides has been identified as the first lymphocyte-specific member
of the gene family characterized by seven transmembrane-spanning regions.
Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color
flow cytometry it is shown that BLR1 expression on peripheral blood cells
is limited to B cells and to a subset of CD4+ (14%) and CD8+ (2%)
lymphocytes. T cells expressing BLR1 were positive for CD45R0, were
negative for interleukin-2 receptors, show high levels of CD44, and show
low levels of L-selectin. The majority of CD4+ cells originating from
secondary lymphatic tissue, but none of cord blood- derived T cells,
express BLR1. These observations suggest that BLR1 is a marker for memory T
cells. Furthermore, BLR1 expression was detected on all CD19+ peripheral or
tonsillar B lymphocytes, but only on a fraction of cord blood cells and
bone marrow cells expressing CD19, sIgM, or sIgD. Interestingly, activation
of both mature B and T cells by CD40 MoAb and CD3 MoAb, respectively, led
to complete downregulation of BLR1. These data suggest that the
G-protein-coupled receptor BLR1 is involved in functional control of mature
recirculating B cells and T- helper memory cells participating in cell
migration and cell activation.
Volume 84,
Issue 3,
pp. 830-840,
08/01/1994
Copyright © 1994 by The American Society of Hematology
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