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Differential regulation of alpha and beta chains of C4b-binding protein
during acute-phase response resulting in stable plasma levels of free
anticoagulant protein S
P Garcia de Frutos, RI Alim, Y Hardig, B Zoller and B Dahlback
Department of Clinical Chemistry, University of Lund, Malmo General
Hospital, Sweden.
Regulation of C4b-binding protein (C4BP) isoforms during acute phase and
its relationship to the plasma concentration of free protein S was
elucidated. An assay for beta chain containing C4BP (C4BP beta+) was
developed and the concentrations of total C4BP, C4BP beta+, total, free,
and bound protein S were measured in patients with acute-phase response.
Even though total C4BP was increased to 162% (mean value) of controls, the
corresponding value of C4BP beta+ was only 122%. In the acute-phase group,
total protein S was increased to the same extent as C4BP beta+ (mean value
of 124%), whereas free protein S was not decreased. In controls, total and
bound protein S correlated with total C4BP and C4BP beta+. However, in the
acute-phase group, the correlation between bound protein S and total C4BP
was lost, although the correlation between C4BP beta+ and protein S
remained. The present results suggest stable levels of free protein S
during acute phase to be the result of differential regulation of C4BP
alpha- and beta-chain expression, and the concentration of free protein S
to be the resulting molar excess of protein S over C4BP beta+. This
mechanism ensures functional levels of free anticoagulant protein S despite
high levels of C4BP.
Volume 84,
Issue 3,
pp. 815-822,
08/01/1994
Copyright © 1994 by The American Society of Hematology
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