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Progesterone-associated endometrial protein--a constitutive marker of human
erythroid precursors
M Kamarainen, L Riittinen, M Seppala, A Palotie and LC Andersson
Department I of Obstetrics and Gynecology, University of Helsinki, Finland.
Progesterone-associated endometrial protein (PAEP/PP14) is a 28-kD
glycoprotein with sequence homology to beta-lactoglobulins containing a
retinol-binding motif. PAEP/PP14 is present at nanomolar concentrations in
human serum. It is produced by secretory and decidualized endometrium in
women and by seminal vesicle epithelium in men. We report here that PAEP
mRNA is constitutively expressed in normal hematopoietic tissue. Western
immunoblotting of bone marrow cells with rabbit antibodies to PAEP gave a
band at 28 kD, and immunocytochemical staining with monoclonal antibodies
localized PAEP into the cytoplasm of erythroid precursors representing
different stages of the normoblast series. PAEP was not detected in mature
red blood cells, platelets, or in cells of the myeloid lineage. Untreated
K562 leukemia cells did not contain PAEP, whereas treatment of the cells
with tetradecanoylphorbol acetate (TPA) induced strong expression of PAEP
mRNA and synthesis of the intact protein that was found both in the
cytoplasm of the differentiating cells and in the supernatant of
TPA-treated cultures. These findings add a new member to the growing family
of genes that are constitutively expressed both in the reproductive tract
and in the hematopoietic system.
Volume 84,
Issue 2,
pp. 467-473,
07/15/1994
Copyright © 1994 by The American Society of Hematology
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