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Stem cell factor enhances the survival but not the self-renewal of murine
hematopoietic long-term repopulating cells
CL Li and GR Johnson
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne
Hospital, Victoria, Australia.
The effects of stem cell factor (SCF) have been tested on a murine bone
marrow subpopulation (RH123lo, Lin-, Ly6A/E+) that is highly enriched for
long-term hematopoietic repopulating cells. SCF maintained cells from this
population with long-term repopulating ability for up to 10 days in vitro.
However, compared with freshly isolated cells, the level of engraftment in
vivo by the cultured cells declined during the in vitro culture period,
suggesting that SCF alone was unable to stimulate the self-renewal of
long-term repopulating cells. By direct visualization of cultures, only
small numbers of cells survived and rarely underwent cell division.
However, SCF did directly stimulate proliferation of a population
(Rh123med/hi,Lin-,Ly6A/E+) enriched for short-term repopulating cells.
These data suggest that stem cell differentiation is associated with the
development of mitogenic activity by SCF at least in some progenitor cell
populations.
Volume 84,
Issue 2,
pp. 408-414,
07/15/1994
Copyright © 1994 by The American Society of Hematology
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