|
|
 Previous Article | Table of Contents | Next Article 
Mantle cell (previously centrocytic) lymphomas express VH genes with no or
very little somatic mutations like the physiologic cells of the follicle
mantle
M Hummel, J Tamaru, B Kalvelage and H Stein
Institute of Pathology, Klinikum Steglitz, Free University Berlin, Germany.
To clarify whether mantle cell lymphomas (MCLs) are related to naive
pre-germinal center B cells (expressing nonmutated rearranged VH genes) or
to germinal center-derived memory B cells (expressing mutated rearranged VH
genes), clonal IgH gene rearrangements using DNA from six MCLs were
polymerase chain reaction (PCR)-amplified and analyzed for the presence of
somatic mutations. For comparison, six cases of B- chronic lymphocytic
leukemia (B-CLL) known to display nonmutated rearranged VH genes and six
cases of follicle center lymphomas (FCLs) known to display mutated
rearranged VH genes were included in our study. The VH region sequences of
the six MCLs showed, like those of the six B-CLL cases, no or very little
somatic mutations, in contrast to the VH sequences of the six FCL cases,
all of which were highly mutated. This is indicative of MCL, like B-CLL,
being derived from naive pre-germinal center B cells and furthermore
underscores the postulated relationship of MCLs with the B cells of the
normal follicular mantle zone because it has recently been shown that this
mantle zone is solely or at least largely composed of naive (nonmutated) B
cells.
Volume 84,
Issue 2,
pp. 403-407,
07/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Sander, L. Bullinger, E. Leupolt, A. Benner, D. Kienle, T. Katzenberger, J. Kalla, G. Ott, H. K. Muller-Hermelink, T. F.E. Barth, et al.
Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations
Haematologica,
May 1, 2008;
93(5):
680 - 687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Coupland, M. Hummel, H.-H. Muller, and H. Stein
Molecular Analysis of Immunoglobulin Genes in Primary Intraocular Lymphoma
Invest. Ophthalmol. Vis. Sci.,
October 1, 2005;
46(10):
3507 - 3514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Orchard, R. Garand, Z. Davis, G. Babbage, S. Sahota, E. Matutes, D. Catovsky, P. W. Thomas, H. Avet-Loiseau, and D. Oscier
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease
Blood,
June 15, 2003;
101(12):
4975 - 4981.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. I. Camacho, P. Algara, A. Rodriguez, E. Ruiz-Ballesteros, M. Mollejo, N. Martinez, J. A. Martinez-Climent, M. Gonzalez, M. Mateo, A. Caleo, et al.
Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations
Blood,
May 15, 2003;
101(10):
4042 - 4046.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Bahler, J. A. Pindzola, and S. H. Swerdlow
Splenic Marginal Zone Lymphomas Appear to Originate from Different B Cell Types
Am. J. Pathol.,
July 1, 2002;
161(1):
81 - 88.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Algara, M. S. Mateo, M. Sanchez-Beato, M. Mollejo, I. C. Navas, L. Romero, F. Sole, M. Salido, L. Florensa, P. Martinez, et al.
Analysis of the IgVH somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course
Blood,
February 15, 2002;
99(4):
1299 - 1304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Taylor, J. A. Pittman, K. Seeberger, M. J. Mant, T. Reiman, A. R. Belch, and L. M. Pilarski
Intraclonal Homogeneity of Clonotypic Immunoglobulin M and Diversity of Nonclinical Post-Switch Isotypes in Multiple Myeloma: Insights into the Evolution of the Myeloma Clone
Clin. Cancer Res.,
February 1, 2002;
8(2):
502 - 513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hara, N. Nakamura, T. Kuze, Y. Hashimoto, Y. Sasaki, A. Shirakawa, M. Furuta, K. Yago, K. Kato, and M. Abe
Immunoglobulin Heavy Chain Gene Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma
Invest. Ophthalmol. Vis. Sci.,
October 1, 2001;
42(11):
2450 - 2457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Welzel, T. Le, R. Marculescu, G. Mitterbauer, A. Chott, C. Pott, M. Kneba, M.-Q. Du, R. Kusec, J. Drach, et al.
Templated Nucleotide Addition and Immunoglobulin JH-Gene Utilization in t(11;14) Junctions: Implications for the Mechanism of Translocation and the Origin of Mantle Cell Lymphoma
Cancer Res.,
February 1, 2001;
61(4):
1629 - 1636.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Nihal, D. Mikkola, and G. S. Wood
Detection of Clonally Restricted Immunoglobulin Heavy Chain Gene Rearrangements in Normal and Lesional Skin: Analysis of the B Cell Component of the Skin-Associated Lymphoid Tissue and Implications for the Molecular Diagnosis of Cutaneous B Cell Lymphomas
J. Mol. Diagn.,
February 1, 2000;
2(1):
5 - 10.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Marafioti, M. Hummel, I. Anagnostopoulos, H.-D. Foss, D. Huhn, and H. Stein
Classical Hodgkin's Disease and Follicular Lymphoma Originating From the Same Germinal Center B Cell
J. Clin. Oncol.,
December 1, 1999;
17(12):
3804 - 3809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kuppers, U. Klein, M.-L. Hansmann, and K. Rajewsky
Cellular Origin of Human B-Cell Lymphomas
N. Engl. J. Med.,
November 11, 1999;
341(20):
1520 - 1529.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Stein, M. Hummel, P. Korbjuhn, H.-D. Foss, I. Anagnostopoulos, T. Marafioti, and H. Stein
Monocytoid B Cells Are Distinct From Splenic Marginal Zone Cells and Commonly Derive From Unmutated Naive B Cells and Less Frequently From Postgerminal Center B Cells by Polyclonal Transformation
Blood,
October 15, 1999;
94(8):
2800 - 2808.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Teitell, M. A. Damore, G. G. Sulur, D. E. Turner, M.-H. Stern, J. W. Said, C. T. Denny, and R. Wall
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues
PNAS,
August 17, 1999;
96(17):
9809 - 9814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.M. Aarts, R. Willemze, R.J. Bende, C.J.L.M. Meijer, S.T. Pals, and C.J.M. van Noesel
VH Gene Analysis of Primary Cutaneous B-Cell Lymphomas: Evidence for Ongoing Somatic Hypermutation and Isotype Switching
Blood,
November 15, 1998;
92(10):
3857 - 3864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. KUROSU, N. YUMOTO, M. FURUKAWA, T. KURIYAMA, and A. MIKATA
Low-Grade Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma with or without Intraclonal Variation
Am. J. Respir. Crit. Care Med.,
November 1, 1998;
158(5):
1613 - 1619.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. K. Muller-Hermelink and A. Greiner
Molecular Analysis of Human Immunoglobulin Heavy Chain Variable Genes (IgVH) in Normal and Malignant B Cells
Am. J. Pathol.,
November 1, 1998;
153(5):
1341 - 1346.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-W. Vaandrager, E. Schuuring, H. C. Kluin-Nelemans, M. J.S. Dyer, A. K. Raap, and P. M. Kluin
DNA Fiber Fluorescence In Situ Hybridization Analysis of Immunoglobulin Class Switching in B-Cell Neoplasia: Aberrant CH Gene Rearrangements in Follicle Center-Cell Lymphoma
Blood,
October 15, 1998;
92(8):
2871 - 2878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Dorfman, A. Shahsafaei, L. M. Nadler, and G. J. Freeman
The Leukocyte Semaphorin CD100 Is Expressed in Most T-Cell, but Few B-Cell, Non-Hodgkin's Lymphomas
Am. J. Pathol.,
July 1, 1998;
153(1):
255 - 262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tierens, J. Delabie, S. Pittaluga, A. Driessen, and C. DeWolf-Peeters
Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B Lymphocyte Subsets
Blood,
April 1, 1998;
91(7):
2381 - 2386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Taniguchi, K. Oka, A. Hiasa, M. Yamaguchi, T. Ohno, K. Kita, and H. Shiku
De Novo CD5+ Diffuse Large B-Cell Lymphomas Express VH Genes With Somatic Mutation
Blood,
February 15, 1998;
91(4):
1145 - 1151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Andersen, J. W. Donovan, J. S. Borus, C. M. Poor, D. Neuberg, J. C. Aster, L. M. Nadler, A. S. Freedman, and J. G. Gribben
Failure of Immunologic Purging in Mantle Cell Lymphoma Assessed by Polymerase Chain Reaction Detection of Minimal Residual Disease
Blood,
November 15, 1997;
90(10):
4212 - 4221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Marafioti, M. Hummel, I. Anagnostopoulos, H.-D. Foss, B. Falini, G. Delsol, P. G. Isaacson, S. Pileri, and H. Stein
Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells
N. Engl. J. Med.,
August 14, 1997;
337(7):
453 - 458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gahn, C. Schafer, J. Neef, C. Troff, M. Feuring-Buske, W. Hiddemann, and B. Wormann
Detection of Trisomy 12 and Rb-Deletion in CD34+ Cells of Patients With B-Cell Chronic Lymphocytic Leukemia
Blood,
June 15, 1997;
89(12):
4275 - 4281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Bahler, J. A. Miklos, and S. H. Swerdlow
Ongoing Ig Gene Hypermutation in Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphomas
Blood,
May 1, 1997;
89(9):
3335 - 3344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hummel, K. Ziemann, H. Lammert, S. Pileri, E. Sabattini, and H. Stein
Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed-Sternberg Cells
N. Engl. J. Med.,
October 5, 1995;
333(14):
901 - 906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
