|
|
 Previous Article | Table of Contents | Next Article 
Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-
associated non-Hodgkin's lymphoma: association with diffuse large-cell
subtype
G Gaidano, F Lo Coco, BH Ye, D Shibata, AM Levine, DM Knowles and R Dalla-Favera
Department of Pathology, College of Physicians and Surgeons, Columbia
University, New York, NY 10032.
Acquired immunodeficiency syndrome (AIDS)-associated non-Hodgkin's
lymphomas (AIDS-NHL), a major source of morbidity and mortality among AIDS
patients, are derived from B cells and can be classified into two main
histologic categories, small noncleaved cell lymphoma (SNCCL) and diffuse
large-cell lymphoma (DLCL). DLCL includes two histologic subsets, ie, large
noncleaved cell lymphoma (LNCCL) and large cell- immunoblastic plasmacytoid
lymphoma (LC-IBPL). Several studies have shown that AIDS-SNCCL is
associated with the clonal accumulation of multiple genetic lesions,
including Epstein-Barr virus (EBV) infection, activation of the c-MYC and
RAS oncogenes, as well as inactivation of the p53 tumor suppressor gene at
variable frequencies. On the contrary, the molecular pathogenesis of
AIDS-DLCL is largely obscure, because no genetic lesion other than EBV
infection has been specifically identified in this group. In this study, we
have tested a panel of 40 AIDS-NHL for structural alterations of BCL-6, a
putative proto-oncogene that is frequently altered in DLCL in the
immunocompetent host. Our results show that rearrangements of BCL-6 are
present in 20% of AIDS- DLCL (5 of 24), including 2 of 8 LNCCL and 3 of 16
LC-IBPL, but in no case of AIDS-SNCCL. BCL-6 rearrangements were detected
both in the presence and in the absence of EBV infection of the tumor
clone, but in no case were associated with activation of c-MYC or mutations
of p53. These data identify a novel genetic lesion in AIDS-DLCL and
corroborate the notion that lymphomagenesis in AIDS follows two distinct
molecular pathways that are associated with the development of
histologically distinct types of AIDS-NHL.
Volume 84,
Issue 2,
pp. 397-402,
07/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. W. Otieno, C. Banura, E. Katongole-Mbidde, J. L. Johnson, M. Ghannoum, A. Dowlati, R. Renne, E. Arts, C. Whalen, M. M. Lederman, et al.
Therapeutic Challenges of AIDS-Related Non-Hodgkin's Lymphoma in the United States and East Africa
J Natl Cancer Inst,
May 15, 2002;
94(10):
718 - 732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick, G. Carlile, K. F. Ahmad, C.-L. Kiang, C. Corcoran, V. Bardwell, G. G. Prive, and J. D. Licht
Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors
Mol. Cell. Biol.,
March 15, 2002;
22(6):
1804 - 1818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kahnt, K. Matz-Rensing, P. Hofmann, C. Stahl-Hennig, and F.-J. Kaup
SIV-associated Lymphomas in Rhesus Monkeys (Macaca mulatta) in Comparison with HIV-associated Lymphomas
Vet. Pathol.,
January 1, 2002;
39(1):
42 - 55.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sei, D. P. O'Neill, S. K. Stewart, Q.-e. Yang, M. Kumagai, A. M. Boler, M. A. Adde, S. L. Zwerski, L. V. Wood, D. J. Venzon, et al.
Increased Level of Stromal Cell-Derived Factor-1 mRNA in Peripheral Blood Mononuclear Cells from Children with AIDS-related Lymphoma
Cancer Res.,
July 1, 2001;
61(13):
5028 - 5037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hyjek, A. Chadburn, Y. F. Liu, E. Cesarman, and D. M. Knowles
BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus
Blood,
January 1, 2001;
97(1):
270 - 276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Powles, G. Matthews, and M. Bower
AIDS related systemic non-Hodgkin's lymphoma
Sex Transm Inf,
October 1, 2000;
76(5):
335 - 341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G.S. Chirivi, G. Taraboletti, M. R. Bani, L. Barra, G. Piccinini, M. Giacca, F. Bussolino, and R. Giavazzi
Human Immunodeficiency Virus-1 (HIV-1)-Tat Protein Promotes Migration of Acquired Immunodeficiency Syndrome-Related Lymphoma Cells and Enhances Their Adhesion to Endothelial Cells
Blood,
September 1, 1999;
94(5):
1747 - 1754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Teitell, M. A. Damore, G. G. Sulur, D. E. Turner, M.-H. Stern, J. W. Said, C. T. Denny, and R. Wall
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues
PNAS,
August 17, 1999;
96(17):
9809 - 9814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carbone, A. Gloghini, G. Gaidano, S. Franceschi, D. Capello, H. G. Drexler, B. Falini, and R. Dalla-Favera
Expression Status of BCL-6 and Syndecan-1 Identifies Distinct Histogenetic Subtypes of Hodgkin's Disease
Blood,
October 1, 1998;
92(7):
2220 - 2228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Larocca, D. Capello, A. Rinelli, S. Nori, A. Antinori, A. Gloghini, A. Cingolani, A. Migliazza, G. Saglio, S. Cammilleri-Broet, et al.
The Molecular and Phenotypic Profile of Primary Central Nervous System Lymphoma Identifies Distinct Categories of the Disease and Is Consistent With Histogenetic Derivation From Germinal Center-Related B Cells
Blood,
August 1, 1998;
92(3):
1011 - 1019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Nicolaides, S. Dimou, and N. Pavlidis
Prognostic Factors in Aggressive Non-Hodgkin's Lymphomas
Oncologist,
June 1, 1998;
3(3):
189 - 197.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. Gaidano, A. Carbone, and R. Dalla-Favera
Genetic Basis of Acquired Immunodeficiency Syndrome-Related Lymphomagenesis
J Natl Cancer Inst Monographs,
April 1, 1998;
1998(23):
95 - 100.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Moses, J. Nelson, and G. C. Bagby Jr
The Influence of Human Immunodeficiency Virus-1 on Hematopoiesis
Blood,
March 1, 1998;
91(5):
1479 - 1495.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carbone, G. Gaidano, A. Gloghini, L. M. Larocca, D. Capello, V. Canzonieri, A. Antinori, U. Tirelli, B. Falini, and R. Dalla-Favera
Differential Expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Identifies Distinct Histogenetic Subsets of Acquired Immunodeficiency Syndrome-Related Non-Hodgkin's Lymphomas
Blood,
February 1, 1998;
91(3):
747 - 755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Gaidano, A. Carbone, C. Pastore, D. Capello, A. Migliazza, A. Gloghini, S. Roncella, M. Ferrarini, G. Saglio, and R. Dalla-Favera
Frequent Mutation of the 5' Noncoding Region of the BCL-6 Gene in Acquired Immunodeficiency Syndrome-Related Non-Hodgkin's Lymphomas
Blood,
May 15, 1997;
89(10):
3755 - 3762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
