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Identification of potential hot spots in the carboxy-terminal part of the
Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign
EBV-associated diseases: high frequency of a 30-bp deletion in Malaysian
and Danish peripheral T-cell lymphomas
K Sandvej, SC Peh, BS Andresen and G Pallesen
Department of Pathology, Aarhus University Hospital, Denmark.
In this study, we have sequenced the C-terminal part of the Epstein- Barr
virus (EBV)-BNLF-1 gene encoding for the latent membrane protein-1 from
tissues of EBV-positive Danish Hodgkin's disease (HD) and of Danish and
Malaysian peripheral T-cell lymphomas (PTLs) and from tonsils of Danish
infectious mononucleosis (IM). Our study showed that some of the 7
single-base mutations and the 30-bp deletion previously detected between
codons of amino acid 322 and 366 in the BNLF-1 gene of the nasopharyngeal
carcinoma cell line CAO were present in all Malaysian PTLs and in 60% of
the Danish PTLs. In HD and the IM cases, the mutations were present in
about 30%. The 30-bp deletion and the single base mutations occurred
independently, and mutations were detectable in the majority of EBV type
B-positive cases. These findings suggest that the 30-bp deletion and the 7
single-base mutations in the C-terminal part of the CAO-BNLF-1 gene do not
characterize a new EBV type A substrain. Rather, some of the positions of
single base mutations and the 30-bp deletion are hot spots that may have
mutated independently through the evolution of EBV strains.
Volume 84,
Issue 12,
pp. 4053-4060,
12/15/1994
Copyright © 1994 by The American Society of Hematology
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