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The histopathology of splenic lymphoma with villous lymphocytes
PG Isaacson, E Matutes, M Burke and D Catovsky
Department of Histopathology, UCL Medical School, London.
Whereas the hematologic, immunophenotypic, and molecular characteristics of
splenic lymphoma with villous lymphocytes (SLVL) have been well documented,
the histologic features of the spleen and lymph nodes remain
uncharacterized. We have reviewed the histopathology of the spleen in 37
cases of SLVL and of involved splenic hilar lymph nodes in 6 cases. Tissue
immunophenotyping was performed in 24 cases, 6 of which had frozen tissue
available, and the results were compared with the membrane immunophenotype
of the circulating villous lymphocytes and cells extracted from spleen and
lymph nodes. In the spleen, SLVL is characterized by involvement of the
white pulp follicles, which may be surrounded or replaced by the lymphoma
cells. In the red pulp, the cells form small nodules and infiltrate
diffusely with sinusoidal invasion. The cytologic appearance of the
neoplastic cells varies from a resemblance to small mantle-zone--like
lymphocytes to that of marginal-zone cells and there are scattered blast
forms. In involved lymph nodes, the infiltrate again centers on the
follicles that are usually replaced, but occasionally show preservation of
follicle centers; sinuses are often preserved. The tissue immunophenotype
is similar to that of marginal-zone B cells. Membrane immunophenotyping may
give different results in some cases and may vary depending on the
compartment from which the cells are obtained. SLVL in the peripheral blood
is a histologically homogeneous entity identical to the condition
previously characterised by histopathologists as splenic marginal-zone
lymphoma.
Volume 84,
Issue 11,
pp. 3828-3834,
12/01/1994
Copyright © 1994 by The American Society of Hematology
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