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Prevalence and clinical correlations of MLL gene rearrangements in AML-
M4/5
M Bower, P Parry, M Carter, DM Lillington, J Amess, TA Lister, G Evans and BD Young
Molecular Genetics Laboratory, Centre for Human Genome Research, Salk
Institute for Biological Studies, San Diego, CA.
Rearrangements of the human trithorax gene (MLL, HRX, Htrx-1, All-1) were
studied by Southern blotting in blast cells stored at presentation from 65
adults with de novo acute myelomonocytic (AML-M4) and acute monocytic
leukemia (AML-M5). MLL rearrangements were demonstrated in 15 (23%) cases,
including eight patients in whom karyotype analysis had failed to detect
abnormalities of chromosome band 11q23. The patients with MLL
rearrangements did not differ significantly from those with germline
configurations in terms of the sex and age of the patients, the presence of
lymphadenopathy, hepatosplenomegaly, or central nervous system involvement,
and the absolute blast count at diagnosis. Kaplan- Meier analysis of the
treated patients demonstrated no difference in survival for patients with
MLL rearrangements compared with those without rearrangements. Therefore,
in contrast to infantile acute leukemia, in adults with AML-M4 and AML-M5,
MLL rearrangements do not identify a subgroup of patients with different
clinical features or prognosis.
Volume 84,
Issue 11,
pp. 3776-3780,
12/01/1994
Copyright © 1994 by The American Society of Hematology
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