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B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex
translocation involving 18q21.3 but lacking BCL2 rearrangement and
expression
E Nacheva, MJ Dyer, C Metivier, D Jadayel, G Stranks, R Morilla, JM Heward, T Holloway, S O'Connor and PC Bevan
Department of Haematology, University of Cambridge, UK.
A B-cell non-Hodgkin's lymphoma (B-NHL) cell line (Karpas 1106) with an
unusual three-way translocation involving 18q21.3 has been derived from a
patient with mediastinal lymphoblastic B-NHL. Although conventional
cytogenetics showed a derivative 18q-identical to that seen in cases with
t(14;18)(q32.3;q21.3), no translocations of either chromosome 14 could be
detected. Instead fluorescent in situ hybridization analysis using a
chromosome-18 paint showed that the segment 18q21.3-18qter had become
sandwiched on a derivative chromosome X between segments Xqter-c- Xq28 and
13q12-qter, with the centrometric site of 18q21.3 subband juxtaposed to the
X sequences. Pulsed-field DNA blots failed to detect rearrangement of the
BCL2 gene. Conventional DNA blots using a variety of restriction digests
and both 5' and 3' BCL2 and FVT 1 probes also failed to detect
rearrangement in Karpas 1106. A rearranged fragment seen only in HindIII
digests with 5' BLC2 probes may represent a local microalteration, which is
either a mutation or small deletion involving the HindIII site as seen in
other cases of B-NHL. Neither BCL2 RNA nor BCL2 protein expression were
detected. These and other data suggest that genes at 18q21.3, other than
BCL2 and FVT1, may be targets for translocation in certain subgroups of
B-NHL.
Volume 84,
Issue 10,
pp. 3422-3428,
11/15/1994
Copyright © 1994 by The American Society of Hematology
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