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Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6- associated
bone marrow suppression in bone marrow transplant patients [see comments]
DR Carrigan and KK Knox
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
These studies tested the hypothesis that human herpesvirus 6 (HHV-6) can
cause posttransplant bone marrow (BM) suppression in BM transplant (BMT)
patients. Fifteen adult patients who received T-lymphocyte- depleted,
allogeneic BM transplants and who developed posttransplant BM suppression
were studied. Detailed chart reviews were used to divide the patients into
two groups: (1) those with diagnosed BM suppression (DBMS) and (2) those
with idiopathic BM suppression (IBMS). BM aspirates obtained from the
patients at the onset of BM suppression were subjected to an HHV-6
isolation procedure using mitogen-stimulated blood mononuclear cells. BM
specimens obtained from another population of BMT patients solely to
document engraftment irrespective of their BM function were also subjected
to the HHV-6 isolation procedure as controls. HHV-6 was isolated from 6 of
15 BM samples from BMT patients with BM suppression. BM samples from
patients with IBMS were more likely to be positive for HHV-6 than those
from patients with DBMS (P < .01). Also, HHV-6-positive BM were
significantly more likely (P < .05) to come from patients with
suppression of more than one BM lineage than HHV-6-negative BM. Finally,
samples of BM from an unselected series of BMT patients studied without
regard to their BM function were less likely (P < .01) to be positive
for HHV-6 than patients with IBMS.
Volume 84,
Issue 10,
pp. 3307-3310,
11/15/1994
Copyright © 1994 by The American Society of Hematology
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