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Expression of adult and fetal natural killer cell markers in sinonasal
lymphomas [see comments]
J Suzumiya, M Takeshita, N Kimura, M Kikuchi, T Uchida, S Hisano, Y Eura, M Kozuru, Y Nomura and K Tomita
First Department of Internal Medicine, School of Medicine, Fukuoka
University, Japan.
The majority of sinonasal non-Hodgkin's lymphomas (NHLs) are thought to
originate from T-cell lineage. However, they often express natural killer
(NK)-cell markers so that their origin still remains obscure. In this
study, cell type of sinonasal NHLs were characterized by
immunohistochemical and Southern blot analyses. We examined nine patients
with sinonasal NHL. Six patients with tonsillar or pharyngeal non-B-cell
lymphomas served as a control group. Immunohistochemical study showed that
all nine cases of sinonasal NHL were CD56+CD2+, whereas controls were
CD56-CD2+. According to the rearrangement of T- cell receptors (TCRs) and
expression of CD3 markers, the sinonasal NHL cases were classified into
three groups: TCR-CD56(Leu-19)+CD3(Leu4)- NHL (three patients),
TCR-CD56+CD3+ NHL (five patients), and TCR+CD56+CD3+ NHL (one patient). In
contrast, control patients' NHLs were TCR+CD56-CD3+. These results imply
that eight cases of TCR-CD56+ sinonasal NHL are of NK-cell lineage. Among
these eight cases, TCR- CD56+CD3+ cases (five of eight patients) were
rather similar to the phenotype of fetal NK cells. From these results, the
majority of sinonasal NHLs seem to originate from varying maturation stages
of NK- cell lineage.
Volume 83,
Issue 8,
pp. 2255-2260,
04/15/1994
Copyright © 1994 by The American Society of Hematology
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